Fruth A, Prager R, Friedrich A, Kuczius T, Roggentin P, Karch H, Ammon A, Bockemühl J, Tschäpe H
Robert Koch-Institut, Bereich Wernigerode, Wernigerode, Germany.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2002 Sep;45(9):715-21. doi: 10.1007/s00103-002-0458-4.
Intestinal infections in Germany due to enterohemorrhagic E. coli bacteria (EHEC) between 1998 and 2001 reveal a large scale of biological diversity of their pathogens. However, no dramatic increase of their clinical importance and public health implications has been observed. As strains of serovar O157:H7 have continuously declined as causative agents, other serovars such as O26:H11 and O103:H2 have replaced them. The great diversity of the EHEC pathogens might point to a great number of various infection routes and sources. Since recently new pathogenic factors of EHEC bacteria have been detected (especially by the sequencing of the genome of EHEC), it is currently not possible to define a clear-cut difference between human pathogens and nonhuman pathogens. The enhanced surveillance of EHEC pathogens with respect to their biological diversity and dynamics, their epidemic spread, and their infection routes and sources remain an essential task of the public health authorities.
1998年至2001年间德国因肠出血性大肠杆菌（EHEC）导致的肠道感染揭示了其病原体具有大规模的生物多样性。然而，未观察到其临床重要性和对公共卫生的影响有显著增加。由于血清型O157:H7菌株作为病原体的比例持续下降，其他血清型如O26:H11和O103:H2已取而代之。EHEC病原体的巨大多样性可能表明存在大量不同的感染途径和来源。由于最近已检测到EHEC细菌的新致病因素（特别是通过对EHEC基因组进行测序），目前尚无法明确界定人类病原体和非人类病原体之间的差异。加强对EHEC病原体的生物多样性和动态变化、其流行传播以及感染途径和来源的监测，仍然是公共卫生当局的一项重要任务。
