Pollak Lea, Stryjer Rafael
Department of Neurology, The Assaf Harofeh Medical Center, Zerifin, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel,
Eur Arch Otorhinolaryngol. 2015 Sep;272(9):2129-33. doi: 10.1007/s00405-014-3041-3. Epub 2014 Apr 12.
Fatigue is characterized by weariness unrelated to exertion levels. It has been reported in chronic neurological diseases such as multiple sclerosis, Parkinson disease and stroke. Patients with benign paroxysmal positional vertigo (BPPV) often complain about fatigue during a vertigo attack. No attention has been paid to this symptom in the literature so far. We were interested to evaluate the frequency and factors influencing fatigue in BPPV. Patients treated for idiopathic BPPV during the years 2011-2012 were prospectively evaluated for the presence of fatigue. During the first visit, patients were asked to complete two questionnaires based on their experience during the last week: the Fatigue severity scale and the Hospital anxiety and depression scale. Patients' demographic data and BPPV characteristics were registered. Among 172 patients treated for BPPV, 40 (23.2 %) reported fatigue. The mean fatigue score was 4.73 ± 1.98 indicating moderate fatigue. No correlation was found between fatigue and anxiety or fatigue and depression. Fatigue scores were inversely related to age (r = -0.36, p = 0.020) and were not dependent on the type of BPPV, its recurrence, background diseases, gender, duration of vertigo or the presence of autonomic symptoms. Moderate fatigue is quite common during an attack of BPPV. It seems to be a genuine symptom of the entity that might worsen patients' distress. For severe or persistent fatigue treatment with fatigue relieving drugs such as amantadine, methylphenidate or modafinil could be tried in the future.
疲劳的特征是与劳累程度无关的疲倦。在慢性神经疾病如多发性硬化症、帕金森病和中风中都有相关报道。良性阵发性位置性眩晕(BPPV)患者在眩晕发作时常常抱怨疲劳。迄今为止,文献中尚未关注到这一症状。我们有兴趣评估BPPV中疲劳的发生率及影响因素。对2011年至2012年期间接受特发性BPPV治疗的患者进行前瞻性疲劳评估。在首次就诊时,要求患者根据其上周的经历完成两份问卷:疲劳严重程度量表和医院焦虑抑郁量表。记录患者的人口统计学数据和BPPV特征。在172例接受BPPV治疗的患者中,40例(23.2%)报告有疲劳。平均疲劳评分为4.73±1.98,表明为中度疲劳。未发现疲劳与焦虑或疲劳与抑郁之间存在相关性。疲劳评分与年龄呈负相关(r = -0.36,p = 0.020),且不依赖于BPPV的类型、复发情况、基础疾病、性别、眩晕持续时间或自主神经症状的存在。在BPPV发作期间,中度疲劳相当常见。它似乎是该疾病的一个真实症状,可能会加重患者的痛苦。对于严重或持续性疲劳,未来可尝试使用如金刚烷胺、哌甲酯或莫达非尼等缓解疲劳的药物进行治疗。