Brain Research Institute, Neuroscience Center Zürich, University of Zürich and Swiss Federal Institute of Technology, Zürich, Switzerland.
Gurdon Institute, Cambridge, UK.
Nat Neurosci. 2014 May;17(5):667-9. doi: 10.1038/nn.3695. Epub 2014 Apr 13.
Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) expression, and behavioral and metabolic responses in the progeny. Injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring.
小型非编码 RNA（sncRNAs）是基因与环境之间的潜在载体。我们发现，早期生活中的创伤性应激改变了小鼠 microRNA（miRNA）的表达，以及后代的行为和代谢反应。将创伤性应激雄性的精子 RNA 注入野生型卵母细胞中，可使后代产生行为和代谢改变。
