Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, USA.
Nat Rev Mol Cell Biol. 2012 Mar 22;13(4):239-50. doi: 10.1038/nrm3313.
MicroRNAs (miRNAs) have recently emerged as key regulators of metabolism. For example, miR-33a and miR-33b have a crucial role in controlling cholesterol and lipid metabolism in concert with their host genes, the sterol-regulatory element-binding protein (SREBP) transcription factors. Other metabolic miRNAs, such as miR-103 and miR-107, regulate insulin and glucose homeostasis, whereas miRNAs such as miR-34a are emerging as key regulators of hepatic lipid homeostasis. The discovery of circulating miRNAs has highlighted their potential as both endocrine signalling molecules and disease markers. Dysregulation of miRNAs may contribute to metabolic abnormalities, suggesting that miRNAs may potentially serve as therapeutic targets for ameliorating cardiometabolic disorders.
微小 RNA（miRNAs）最近被发现是代谢的关键调节因子。例如，miR-33a 和 miR-33b 与它们的宿主基因——固醇调节元件结合蛋白（SREBP）转录因子一起，在控制胆固醇和脂质代谢方面发挥着重要作用。其他代谢 miRNA，如 miR-103 和 miR-107，调节胰岛素和葡萄糖稳态，而 miR-34a 等 miRNA 则作为肝脂质稳态的关键调节因子出现。循环 miRNAs 的发现强调了它们作为内分泌信号分子和疾病标志物的潜在作用。miRNAs 的失调可能导致代谢异常，表明 miRNAs 可能作为改善心脏代谢疾病的治疗靶点。
