Hu Yueqing, Tang Wenjing, Liu Ruozhuo, Dong Zhao, Chen Xiaoyan, Pan Meiyan, Yu Shengyuan
Department of Neurology, Chinese PLA General Hospital, Beijing, PR China.
Department of Neurology, Chinese PLA General Hospital, Beijing, PR China
Cephalalgia. 2014 Dec;34(14):1142-9. doi: 10.1177/0333102414531153. Epub 2014 Apr 11.
The existence of an association between migraine and essential tremor has long been controversial. The prevalence of migraine in essential tremor patients was surveyed to explore the association between the two diseases.
A case-control clinical study was conducted to investigate the prevalence of migraine in 150 consecutive essential tremor patients and in 150 matched controls without tremor. Detailed information about essential tremor and migraine was obtained using a structured questionnaire at a face-to-face interview. Moreover, a functional variant of the dopamine receptor D3 gene (Ser9Gly, rs6280) was studied in 46 essential tremor patients with and without migraine using direct sequencing analysis.
The prevalence of lifetime migraine in essential tremor patients was significantly higher than that in controls (22.0% vs. 12.7%; p=0.035; odds ratio=1.95; 95% confidence interval=1.05-3.60). No significant difference was found in the migraine features between the essential tremor and control groups and most tremor characteristics were no different in essential tremor patients with and without migraine. A higher male prevalence of essential tremor patients without migraine was observed. Moreover, 44 of 46 (95.7%) essential tremor patients had the dopamine receptor D3 Ser9Gly variant, but no significant difference was found in the frequencies of the variant between essential tremor patients with and without migraine (87.5% vs. 100.0%; p=0.22).
Our data suggest that essential tremor patients have a higher risk of lifetime migraine than do controls and the dopamine receptor D3 Ser9Gly variant may be lower in essential tremor with migraine than the general essential tremor patients.
偏头痛与特发性震颤之间是否存在关联长期以来一直存在争议。对特发性震颤患者中偏头痛的患病率进行了调查，以探讨这两种疾病之间的关联。
进行了一项病例对照临床研究，调查150例连续的特发性震颤患者以及150例匹配的无震颤对照者中偏头痛的患病率。在面对面访谈中使用结构化问卷获取有关特发性震颤和偏头痛的详细信息。此外，使用直接测序分析研究了46例有或无偏头痛的特发性震颤患者中多巴胺受体D3基因的一个功能变异（Ser9Gly，rs6280）。
特发性震颤患者终生偏头痛的患病率显著高于对照组（22.0%对12.7%；p = 0.035；比值比 = 1.95；95%置信区间 = 1.05 - 3.60）。特发性震颤组和对照组之间的偏头痛特征无显著差异，大多数震颤特征在有和无偏头痛的特发性震颤患者中也无差异。观察到无偏头痛的特发性震颤患者中男性患病率较高。此外，46例特发性震颤患者中有44例（95.7%）具有多巴胺受体D3 Ser9Gly变异，但有和无偏头痛的特发性震颤患者之间该变异的频率无显著差异（87.5%对100.0%；p = 0.22）。
我们的数据表明，特发性震颤患者终生患偏头痛的风险高于对照组，并且偏头痛性特发性震颤患者中多巴胺受体D3 Ser9Gly变异可能低于一般特发性震颤患者。
