环金属化铱（III）-β-咔啉配合物作为有效的自噬诱导剂。
Cyclometalated iridium(III)-β-carboline complexes as potent autophagy-inducing agents.
作者信息
He Liang, Liao Si-Yan, Tan Cai-Ping, Lu Yi-Ying, Xu Cui-Xia, Ji Liang-Nian, Mao Zong-Wan
机构信息
MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, P. R. China.
出版信息
Chem Commun (Camb). 2014 May 30;50(42):5611-4. doi: 10.1039/c4cc01461h.
PMID:24728495
Abstract
Two cyclometalated Ir(III)-β-carboline complexes were identified as potent inducers of autophagic cell death. Autophagy induced by these complexes is ROS-mediated and caspase-independent.
摘要
两种环金属化铱（III）-β-咔啉配合物被鉴定为自噬性细胞死亡的有效诱导剂。这些配合物诱导的自噬是由活性氧介导的且不依赖半胱天冬酶。
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