Lau Patrick P K, Yau Gordon S K, Lee Jacky W Y, Wong Winnie W Y, Tam Victor T Y, Chan Eric Y T, Tse Doris M W, Yuen Can Y F
Department of Medicine and Geriatric, Caritas Medical Centre, Hong Kong, Special Administrative Region China.
Int Ophthalmol. 2015 Jun;35(3):303-10. doi: 10.1007/s10792-014-9945-5. Epub 2014 Apr 12.
To investigate the etiology and prevalence of optic neuritis in a Chinese population. This was a single centre prospective cohort study. Consecutive patients with either a first or recurrent attack of optic neuritis from November 2010 to December 2011 were recruited from a district hospital in Hong Kong Special Administrative Region, China. All patients underwent serology testing for NMO (neuromyelitis optica) IgG; oligoclonal bands from lumbar puncture; computer tomography and contrast magnetic resonance imaging (MRI) of the brain and orbit as well as visual field; and optical coherence tomography testing. Patients were followed up for 1 year after the initial attack. 30 optic neuritis subjects were recruited. 73.3 % (22/30) remain as clinical isolated syndrome (CIS) after 1-year follow-up. 10 % (3/30) patients developed multiple sclerosis. 10 % (3/30) were diagnosed with NMO and 6.7 % (2/30) with NMO-spectrum disorder. The majority of acute unilateral optic neuritis in Chinese was CIS in origin although a fraction does progress to develop MS or NMO-related disorders. Clinicians should be aware of the associations and offer appropriate systemic workups.
旨在调查中国人群视神经炎的病因及患病率。这是一项单中心前瞻性队列研究。从中国香港特别行政区的一家区级医院招募了2010年11月至2011年12月期间首次发作或复发视神经炎的连续患者。所有患者均接受了视神经脊髓炎（NMO）IgG的血清学检测；腰椎穿刺的寡克隆带检测；脑部和眼眶的计算机断层扫描及对比磁共振成像（MRI）以及视野检查；还有光学相干断层扫描检测。患者在初次发作后随访1年。共招募了30名视神经炎受试者。1年随访后，73.3%（22/30）仍为临床孤立综合征（CIS）。10%（3/30）的患者发展为多发性硬化症。10%（3/30）被诊断为视神经脊髓炎，6.7%（2/30）为视神经脊髓炎谱系障碍。中国人中大多数急性单侧视神经炎起源于临床孤立综合征，尽管有一部分会进展为多发性硬化症或与视神经脊髓炎相关的疾病。临床医生应了解这些关联并提供适当的全身检查。
