Pang Hongcui, Xu Guanglun, Liu Hua, Zhu Xuehai, Zhu Xuewei, Wang Guannan, Zhang Yannan, Yuan Ting, Ji Zhifang, Gao Lishu, Tan Guochang
Department of Hematology, Langfang Hospital of Traditional Chinese Medicine Langfang 065000, Hebei, China.
Department of Rehabilitation, Yantai Penglai Hospital of Traditional Chinese Medicine Yantai 265600, Shandong, China.
Am J Transl Res. 2023 Aug 15;15(8):5304-5313. eCollection 2023.
To investigate the clinical efficacy of Shixuan and Qiduan blood-letting therapy combined with Master Tung's Five-tiger Point (11.27) Scraping for patients with hematological malignancy and peripheral neuritis.
A total of 70 patients with hematological malignancy who were admitted to Langfang TCM Hospital between January 2020 and December 2022 for treating chemotherapy-induced peripheral neuritis were enrolled retrospectively. The patients were divided into a single treatment group that received western nutritional interventions alone, and a combined treatment group that underwent additional Traditional Chinese Medicine (TCM) Shixuan and Qiduan blood-letting therapy, along with Master Tung's Five-tiger Point (11.27) Scraping. Statistical analyses were carried out to compare the clinical efficacy of the two treatment plans in the patients. Scores of sensory disturbance rating (SDR), numeric rating scale (NRS) for pain, nail fold microcirculation (NFM) of the infected extremity, and the quality of life (QoL), as well as the motor nerve conduction velocity (MNCV) and sensory nerve conduction velocity (SNCV) of the median and peroneal nerves of patients in both groups were recorded and compared before and after treatment. The incidence rate of adverse events was compared between the two groups. Furthermore, the clinical outcomes of patients in the two groups were followed up and analyzed for correlated factors using univariate and multivariate analyses.
The clinical efficacy rate achieved by the combined therapy was 88.57%, significantly higher than 68.57% for patients undergoing single therapy (P=0.041). Moreover, the scores of SDR, pain NRS, QoL, and NFM of the affected extremity, as well as the MNCV and SNCV of patients in the two groups were all improved after treatment, with better improvements in the combined treatment group than in the single treatment group. The incidence rate of adverse events was higher in the single treatment group compared to that of the combined treatment group (17.14% vs. 11.42%) (P=0.466). In addition, during the six-month follow-up period, a total of 27 patients in both groups developed chronic neural disorders. Logistic regression analysis revealed that the MNCV and SNCV of the median and peroneal nerves, together with the duration of chemotherapy, served as independent influencing factors.
Shixuan and Qiduan blood-letting therapy combined with Master Tung's Five-tiger Point (11.27) Scraping could improve the SDR and pain NRS scores, facilitate the recovery of neural functions, and advance the QoL of patients with chemotherapy-induced peripheral neuritis without increasing the risk of adverse reactions.
探讨十宣、奇穴放血疗法联合董氏奇穴之五虎穴（11.27）刮痧治疗血液系统恶性肿瘤合并周围神经炎患者的临床疗效。
回顾性纳入2020年1月至2022年12月在廊坊市中医医院收治的70例因化疗所致周围神经炎的血液系统恶性肿瘤患者。将患者分为单纯接受西医营养干预的单一治疗组，以及接受额外的中医十宣、奇穴放血疗法联合董氏奇穴之五虎穴（11.27）刮痧的联合治疗组。对两组患者的治疗方案进行统计学分析以比较临床疗效。记录并比较两组患者治疗前后的感觉障碍评分（SDR）、疼痛数字评分量表（NRS）、患侧肢体甲襞微循环（NFM）、生活质量（QoL），以及正中神经和腓总神经的运动神经传导速度（MNCV）和感觉神经传导速度（SNCV）。比较两组不良事件的发生率。此外，对两组患者的临床结局进行随访，并采用单因素和多因素分析对相关因素进行分析。
联合治疗的临床有效率为88.57%，显著高于单一治疗患者的68.57%（P = 0.041）。此外，两组患者治疗后的SDR、疼痛NRS、QoL、患侧肢体NFM评分，以及MNCV和SNCV均有所改善，联合治疗组的改善程度优于单一治疗组。单一治疗组的不良事件发生率高于联合治疗组（17.14% 对11.42%）（P = 0.466）。此外，在6个月的随访期内，两组共有27例患者出现慢性神经功能障碍。Logistic回归分析显示，正中神经和腓总神经的MNCV和SNCV以及化疗持续时间是独立的影响因素。
十宣、奇穴放血疗法联合董氏奇穴之五虎穴（11.27）刮痧可改善化疗所致周围神经炎患者的SDR和疼痛NRS评分，促进神经功能恢复，提高患者的生活质量，且不增加不良反应风险。
