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低剂量普瑞巴林导致旋转性自我运动感知延迟、轮替运动障碍和眼球跟踪障碍。

Delayed onset of rotatory self-motion perception, dysdiadochokinesia and disturbed eye pursuit caused by low-dose pregabalin.

作者信息

Hounnou Patrice, Nicoucar Keyvan

机构信息

Hôpital du Jura Bernois, Saint-Imier, Switzerland.

出版信息

BMJ Case Rep. 2014 Apr 11;2014:bcr2013201282. doi: 10.1136/bcr-2013-201282.

Abstract

A 30-year-old woman with chronic foot pain after an orthopaedic surgery and chronic neck pain presented to the emergency department (ED) with a history of self-rotatory vertigo with unsteadiness. She had started low-dose pregabalin, 25 mg two times a day 9 months before experiencing symptoms with the dose gradually increased to 150 mg two times a day over this period. Clinical examination revealed difficulty performing eye pursuit with left eye and dysdiadochokinesia of the left arm. Owing to a suspicion of multiple sclerosis she underwent cerebral MRI, which was normal. Pregabalin was tapered over 2 months with a complete disappearance of the symptoms. We concluded that symptoms were due to pregabalin treatment.

摘要

一名30岁女性,骨科手术后患有慢性足部疼痛和慢性颈部疼痛,因自述有旋转性眩晕伴步态不稳前来急诊科就诊。她在出现症状前9个月开始服用低剂量普瑞巴林,每日两次,每次25毫克,在此期间剂量逐渐增加至每日两次,每次150毫克。临床检查发现左眼进行眼球跟踪困难,左臂轮替动作障碍。由于怀疑患有多发性硬化症,她接受了脑部磁共振成像检查,结果正常。普瑞巴林在2个月内逐渐减量,症状完全消失。我们得出结论,症状是由普瑞巴林治疗引起的。

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本文引用的文献

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Pregabalin-induced generalized myoclonic status epilepticus in patients with chronic pain.
Epilepsy Behav. 2007 Nov;11(3):471-3. doi: 10.1016/j.yebeh.2007.06.012. Epub 2007 Sep 27.

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