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1
Delayed onset of rotatory self-motion perception, dysdiadochokinesia and disturbed eye pursuit caused by low-dose pregabalin.低剂量普瑞巴林导致旋转性自我运动感知延迟、轮替运动障碍和眼球跟踪障碍。
BMJ Case Rep. 2014 Apr 11;2014:bcr2013201282. doi: 10.1136/bcr-2013-201282.
2
Disturbance of consciousness and involuntary movements caused by pregabalin.普瑞巴林引起的意识障碍和不自主运动。
BMJ Case Rep. 2012 Nov 28;2012:bcr2012007559. doi: 10.1136/bcr-2012-007559.
3
[Should we care about pregabalin for elderly patients with a history of cardiac dysrhythmia?].[我们应该关注普瑞巴林用于有心脏节律失常病史的老年患者吗?]
Rev Med Interne. 2008 Feb;29(2):152-4. doi: 10.1016/j.revmed.2007.07.009. Epub 2007 Sep 21.
4
Pregabalin reduces opioid consumption and improves outcome in chronic pain patients undergoing total knee arthroplasty.普瑞巴林可减少慢性疼痛患者行全膝关节置换术后阿片类药物的消耗并改善结局。
Phys Sportsmed. 2014 May;42(2):10-8. doi: 10.3810/psm.2014.05.2053.
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[Decompensation of a chronic heart failure associated with pregabalin in a 84-year-old patient: a case report].[84岁患者加巴喷丁所致慢性心力衰竭失代偿:一例报告]
Therapie. 2011 Jan-Feb;66(1):87-8. doi: 10.2515/therapie/2010079.
6
Potential for pregabalin abuse or diversion after past drug-seeking behavior.既往有觅药行为后普瑞巴林滥用或被挪用的可能性。
J Am Osteopath Assoc. 2010 Oct;110(10):605-7.
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[Gait instability revealing a syndrome of inappropriate antidiuretic hormone secretion associated to pregabalin].
Rev Med Interne. 2012 Nov;33(11):e49-51. doi: 10.1016/j.revmed.2012.08.013. Epub 2012 Sep 23.
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Significant improvement of chronic pain by Pregabalin after thoracotomy: report of four cases.胸腔镜手术后普瑞巴林显著改善慢性疼痛:四例报告。
Surg Today. 2013 Aug;43(8):915-7. doi: 10.1007/s00595-012-0287-5. Epub 2012 Aug 5.
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The analgesic effect of pregabalin in patients with chronic pain is reflected by changes in pharmaco-EEG spectral indices.普瑞巴林对慢性疼痛患者的镇痛效果反映在药物-脑电图频谱指数的变化上。
Br J Clin Pharmacol. 2012 Mar;73(3):363-72. doi: 10.1111/j.1365-2125.2011.04104.x.
10
Pregabalin-induced generalized myoclonic status epilepticus in patients with chronic pain.
Epilepsy Behav. 2007 Nov;11(3):471-3. doi: 10.1016/j.yebeh.2007.06.012. Epub 2007 Sep 27.

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Movement disorders associated with antiseizure medications: A systematic review.抗癫痫药物相关运动障碍:系统评价。
Epilepsy Behav. 2022 Jun;131(Pt A):108693. doi: 10.1016/j.yebeh.2022.108693. Epub 2022 Apr 25.
2
Low doses of amitriptyline, pregabalin, and gabapentin are preferred for management of neuropathic pain in India: is there a need for revisiting dosing recommendations?在印度,低剂量的阿米替林、普瑞巴林和加巴喷丁是治疗神经性疼痛的首选药物:是否有必要重新审视给药建议?
Korean J Pain. 2017 Jul;30(3):183-191. doi: 10.3344/kjp.2017.30.3.183. Epub 2017 Jun 30.

本文引用的文献

1
Disturbance of consciousness and involuntary movements caused by pregabalin.普瑞巴林引起的意识障碍和不自主运动。
BMJ Case Rep. 2012 Nov 28;2012:bcr2012007559. doi: 10.1136/bcr-2012-007559.
2
The adverse event profile of pregabalin: a systematic review and meta-analysis of randomized controlled trials.普瑞巴林的不良事件特征:随机对照试验的系统评价和荟萃分析。
Epilepsia. 2011 Apr;52(4):826-36. doi: 10.1111/j.1528-1167.2010.02966.x. Epub 2011 Feb 14.
3
Pregabalin abuse, dependence, and withdrawal: a case report.普瑞巴林滥用、依赖及戒断:一例报告
Am J Psychiatry. 2010 Jul;167(7):869. doi: 10.1176/appi.ajp.2010.09091269.
4
Pregabalin in the treatment of post-traumatic peripheral neuropathic pain: a randomized double-blind trial.普瑞巴林治疗创伤后周围神经性疼痛的随机双盲试验。
Eur J Neurol. 2010 Aug;17(8):1082-9. doi: 10.1111/j.1468-1331.2010.02979.x. Epub 2010 Mar 4.
5
Pregabalin-induced cortical negative myoclonus in a patient with neuropathic pain.普瑞巴林诱发的神经性疼痛患者的皮质负性肌阵挛
Epilepsy Behav. 2008 Aug;13(2):418-20. doi: 10.1016/j.yebeh.2008.04.006. Epub 2008 May 19.
6
Pregabalin-induced generalized myoclonic status epilepticus in patients with chronic pain.
Epilepsy Behav. 2007 Nov;11(3):471-3. doi: 10.1016/j.yebeh.2007.06.012. Epub 2007 Sep 27.
7
Pregabalin: a novel gamma-aminobutyric acid analogue in the treatment of neuropathic pain, partial-onset seizures, and anxiety disorders.普瑞巴林:一种新型γ-氨基丁酸类似物,用于治疗神经性疼痛、部分性发作及焦虑症。
Clin Ther. 2007 Jan;29(1):26-48. doi: 10.1016/j.clinthera.2007.01.013.

低剂量普瑞巴林导致旋转性自我运动感知延迟、轮替运动障碍和眼球跟踪障碍。

Delayed onset of rotatory self-motion perception, dysdiadochokinesia and disturbed eye pursuit caused by low-dose pregabalin.

作者信息

Hounnou Patrice, Nicoucar Keyvan

机构信息

Hôpital du Jura Bernois, Saint-Imier, Switzerland.

出版信息

BMJ Case Rep. 2014 Apr 11;2014:bcr2013201282. doi: 10.1136/bcr-2013-201282.

DOI:10.1136/bcr-2013-201282
PMID:24728890
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3987234/
Abstract

A 30-year-old woman with chronic foot pain after an orthopaedic surgery and chronic neck pain presented to the emergency department (ED) with a history of self-rotatory vertigo with unsteadiness. She had started low-dose pregabalin, 25 mg two times a day 9 months before experiencing symptoms with the dose gradually increased to 150 mg two times a day over this period. Clinical examination revealed difficulty performing eye pursuit with left eye and dysdiadochokinesia of the left arm. Owing to a suspicion of multiple sclerosis she underwent cerebral MRI, which was normal. Pregabalin was tapered over 2 months with a complete disappearance of the symptoms. We concluded that symptoms were due to pregabalin treatment.

摘要

一名30岁女性,骨科手术后患有慢性足部疼痛和慢性颈部疼痛,因自述有旋转性眩晕伴步态不稳前来急诊科就诊。她在出现症状前9个月开始服用低剂量普瑞巴林,每日两次,每次25毫克,在此期间剂量逐渐增加至每日两次,每次150毫克。临床检查发现左眼进行眼球跟踪困难,左臂轮替动作障碍。由于怀疑患有多发性硬化症,她接受了脑部磁共振成像检查,结果正常。普瑞巴林在2个月内逐渐减量,症状完全消失。我们得出结论,症状是由普瑞巴林治疗引起的。