普瑞巴林引起的意识障碍和不自主运动。
Disturbance of consciousness and involuntary movements caused by pregabalin.
作者信息
Shimizu Taro, Yoshida Tsuneyasu, Kitamura Koichi, Hamada Osamu
机构信息
Department of General Medicine, Nerima Hikarigaoka Hospital, Tokyo, Japan.
出版信息
BMJ Case Rep. 2012 Nov 28;2012:bcr2012007559. doi: 10.1136/bcr-2012-007559.
Abstract
A 91-year-old man with chronic low-back pain presented with 1-day history of disturbance of consciousness and myoclonus of all of his extremities and face. Laboratory examinations revealed no abnormalities. Administration of benzodiazepine for the myoclonus resulted in immediate and complete disappearance of the symptoms. He recently started taking pregabalin (Lyrica capsules) which was prescribed for low-back pain 3 days ago. The day following admission, he discontinued pregabalin. He did not experience recurrence of his symptoms any more. We concluded that the neurological symptoms he experienced were possibly due to pregabalin.
摘要
一名91岁的慢性下背痛男性患者，出现意识障碍及四肢和面部肌阵挛1天。实验室检查未发现异常。使用苯二氮䓬类药物治疗肌阵挛后，症状立即完全消失。他最近开始服用普瑞巴林（乐瑞卡胶囊），该药是3天前因下背痛而开具的。入院次日，他停用了普瑞巴林。此后他未再出现症状复发。我们得出结论，他所经历的神经症状可能是由普瑞巴林引起的。
相似文献
1
Disturbance of consciousness and involuntary movements caused by pregabalin.普瑞巴林引起的意识障碍和不自主运动。
BMJ Case Rep. 2012 Nov 28;2012:bcr2012007559. doi: 10.1136/bcr-2012-007559.
2
[Gait instability revealing a syndrome of inappropriate antidiuretic hormone secretion associated to pregabalin].
Rev Med Interne. 2012 Nov;33(11):e49-51. doi: 10.1016/j.revmed.2012.08.013. Epub 2012 Sep 23.
3
Delayed onset of rotatory self-motion perception, dysdiadochokinesia and disturbed eye pursuit caused by low-dose pregabalin.低剂量普瑞巴林导致旋转性自我运动感知延迟、轮替运动障碍和眼球跟踪障碍。
BMJ Case Rep. 2014 Apr 11;2014:bcr2013201282. doi: 10.1136/bcr-2013-201282.
4
Negative myoclonus induced by gabapentin and pregabalin: A case series and systematic literature review.加巴喷丁和普瑞巴林诱发的负性肌阵挛：病例系列和系统文献回顾。
J Neurol Sci. 2017 Nov 15;382:36-39. doi: 10.1016/j.jns.2017.09.019. Epub 2017 Sep 18.
5
Pregabalin- and gabapentin-associated myoclonus in a patient with chronic renal failure.一名慢性肾衰竭患者出现的普瑞巴林和加巴喷丁相关性肌阵挛。
Mov Disord. 2009 Oct 15;24(13):2028-9. doi: 10.1002/mds.22286.
6
Pregabalin-induced generalized myoclonic status epilepticus in patients with chronic pain.
Epilepsy Behav. 2007 Nov;11(3):471-3. doi: 10.1016/j.yebeh.2007.06.012. Epub 2007 Sep 27.
7
[A new anagesic drug: pregabalin; and the first intoxications].
Agri. 2013;25(4):187-9. doi: 10.5505/agri.2013.22448.
8
[Hepatic adverse effects of pregabalin (Lyrica)].[普瑞巴林（乐瑞卡）的肝脏不良反应]
Lakartidningen. 2010;107(4):194.
9
A case of pregabalin intoxication.一例普瑞巴林中毒病例。
Psychiatriki. 2012 Apr-Jun;23(2):162-5.
10
[Decompensation of a chronic heart failure associated with pregabalin in a 84-year-old patient: a case report].[84岁患者加巴喷丁所致慢性心力衰竭失代偿：一例报告]
Therapie. 2011 Jan-Feb;66(1):87-8. doi: 10.2515/therapie/2010079.
引用本文的文献
1
Movement disorders associated with antiseizure medications: A systematic review.抗癫痫药物相关运动障碍：系统评价。
Epilepsy Behav. 2022 Jun;131(Pt A):108693. doi: 10.1016/j.yebeh.2022.108693. Epub 2022 Apr 25.
2
Pregabalin-associated movement disorders: A literature review.普瑞巴林相关的运动障碍：文献综述
Brain Circ. 2020 Jun 26;6(2):96-106. doi: 10.4103/bc.bc_57_19. eCollection 2020 Apr-Jun.
3
Delayed onset of rotatory self-motion perception, dysdiadochokinesia and disturbed eye pursuit caused by low-dose pregabalin.低剂量普瑞巴林导致旋转性自我运动感知延迟、轮替运动障碍和眼球跟踪障碍。
BMJ Case Rep. 2014 Apr 11;2014:bcr2013201282. doi: 10.1136/bcr-2013-201282.
本文引用的文献
1
Pregabalin is a potent and selective ligand for α(2)δ-1 and α(2)δ-2 calcium channel subunits.普瑞巴林是一种有效的、选择性的 α(2)δ-1 和 α(2)δ-2 钙通道亚基配体。
Eur J Pharmacol. 2011 Sep 30;667(1-3):80-90. doi: 10.1016/j.ejphar.2011.05.054. Epub 2011 Jun 1.
2
Evidence-based guideline: Treatment of painful diabetic neuropathy: report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation.循证指南：糖尿病性周围神经痛的治疗：美国神经病学学会、美国神经肌肉与电诊断医学学会和美国物理医学与康复学会的报告。
Neurology. 2011 May 17;76(20):1758-65. doi: 10.1212/WNL.0b013e3182166ebe. Epub 2011 Apr 11.
3
Pregabalin for the discontinuation of long-term benzodiazepines use: an assessment of its effectiveness in daily clinical practice.普瑞巴林用于长期苯二氮䓬类药物停药：对其在日常临床实践中的有效性评估。
Eur Psychiatry. 2012 May;27(4):301-7. doi: 10.1016/j.eurpsy.2010.12.004. Epub 2011 Feb 21.
4
Pregabalin modulation of neurotransmitter release is mediated by change in intrinsic activation/inactivation properties of ca(v)2.1 calcium channels.普瑞巴林通过改变钙通道的内在激活/失活特性来调节神经递质的释放。
J Pharmacol Exp Ther. 2011 Mar;336(3):973-82. doi: 10.1124/jpet.110.172171. Epub 2010 Dec 22.
5
Pharmacological management of neuropathic pain in non-specialist settings: summary of NICE guidance.非专科环境下神经性疼痛的药物治疗：英国国家卫生与临床优化研究所指南摘要
BMJ. 2010 Mar 24;340:c1079. doi: 10.1136/bmj.c1079.
6
Pregabalin in the discontinuation of long-term benzodiazepines' use.普瑞巴林用于长期苯二氮䓬类药物停药
Hum Psychopharmacol. 2008 Jun;23(4):337-40. doi: 10.1002/hup.937.
7
Pharmacologic management of neuropathic pain: evidence-based recommendations.神经性疼痛的药物治疗：循证推荐意见
Pain. 2007 Dec 5;132(3):237-251. doi: 10.1016/j.pain.2007.08.033. Epub 2007 Oct 24.
8
Pharmacological management of chronic neuropathic pain - consensus statement and guidelines from the Canadian Pain Society.慢性神经性疼痛的药物治疗——加拿大疼痛协会的共识声明与指南
Pain Res Manag. 2007 Spring;12(1):13-21. doi: 10.1155/2007/730785.
9
EFNS guidelines on pharmacological treatment of neuropathic pain.欧洲神经科学联合会（EFNS）关于神经性疼痛药物治疗的指南。
Eur J Neurol. 2006 Nov;13(11):1153-69. doi: 10.1111/j.1468-1331.2006.01511.x.
10
Pregabalin reduces the release of synaptic vesicles from cultured hippocampal neurons.普瑞巴林可减少培养的海马神经元中突触小泡的释放。
Mol Pharmacol. 2006 Aug;70(2):467-76. doi: 10.1124/mol.106.023309. Epub 2006 Apr 26.
Zotero 插件