Tronvik Erling, Stovner Lars Jacob
Norwegian National Headache Centre, Department of Neurology, St. Olavs Hospital, Trondheim, Norway,
Curr Pain Headache Rep. 2014 May;18(5):417. doi: 10.1007/s11916-014-0417-4.
The renin-angiotensin system (RAS) is a major regulatory system controlling many different homeostatic mechanisms both within the brain and in the periphery. While it is primarily associated with blood pressure and salt/water regulation, increasing evidence points to the involvement of the RAS in both headache disorders specifically and pain regulation in general. Several publications have indicated that drugs blocking various elements of the renin-angiotensin system lead to a reduction in migraine. Additionally, interventions on different angiotensin peptides or their receptors have been shown to both reduce and increase pain in animal models. As such, modulation of the renin-angiotensin system is a promising approach to the treatment of headaches and other pain conditions.
肾素-血管紧张素系统（RAS）是一个主要的调节系统，控制着大脑和外周的许多不同的稳态机制。虽然它主要与血压和盐/水调节有关，但越来越多的证据表明，RAS特别参与头痛疾病以及一般的疼痛调节。一些出版物表明，阻断肾素-血管紧张素系统各种成分的药物可导致偏头痛减轻。此外，在动物模型中，对不同的血管紧张素肽或其受体进行干预已显示出既能减轻疼痛，也能增加疼痛。因此，调节肾素-血管紧张素系统是治疗头痛和其他疼痛病症的一种有前景的方法。
