Heinz H P, Loos M
Institute of Medical Microbiology, Johannes Gutenberg University, Mainz, FRG.
Complement Inflamm. 1989;6(3):166-74. doi: 10.1159/000463092.
Activation of the classical pathway of complement involves several binding and enzymatic cleavage processes. Binding and enzymatic activation results in the appearance of new structures in the individual components. This report describes the different activation steps for C1q, C1r, C1s, C4 and C2 and summarizes monoclonal antibodies reported so far which recognize either conserved epitopes or activation-dependent epitopes with particular emphasis on neoepitopes occurring during the activation cascade.
补体经典途径的激活涉及多个结合和酶切过程。结合和酶促激活导致各个组分中出现新的结构。本报告描述了C1q、C1r、C1s、C4和C2的不同激活步骤，并总结了迄今为止报道的单克隆抗体，这些抗体识别保守表位或激活依赖性表位，特别强调激活级联过程中出现的新表位。
