Jamal Rahman, Syed Zakaria Syed Zulkifli, Kamaruddin Mohd Arman, Abd Jalal Nazihah, Ismail Norliza, Mohd Kamil Norkhamiwati, Abdullah Noraidatulakma, Baharudin Norhafizah, Hussin Noor Hamidah, Othman Hanita, Mahadi Nor Muhammad
UKM Medical Molecular Biology Institute (UMBI), Department of Paediatrics, Faculty of Medicine, Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, 56000 Kuala Lumpur, Malaysia and Malaysia Genome Institute, Bangi, Selangor, Malaysia
UKM Medical Molecular Biology Institute (UMBI), Department of Paediatrics, Faculty of Medicine, Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, 56000 Kuala Lumpur, Malaysia and Malaysia Genome Institute, Bangi, Selangor, Malaysia.
Int J Epidemiol. 2015 Apr;44(2):423-31. doi: 10.1093/ije/dyu089. Epub 2014 Apr 11.
The Malaysian Cohort study was initiated in 2005 by the Malaysian government. The top-down approach to this population-based cohort study ensured the allocation of sufficient funding for the project which aimed to recruit 100,000 individuals aged 35-70 years. Participants were recruited from rural and urban areas as well as from various socioeconomic groups. The main objectives of the study were to identify risk factors, to study gene-environment interaction and to discover biomarkers for the early detection of cancers and other diseases. At recruitment, a questionnaire-based interview was conducted, biophysical measurements were performed and biospecimens were collected, processed and stored. Baseline investigations included fasting blood sugar, fasting lipid profile, renal profile and full blood count. From April 2006 to the end of September 2012 we recruited a total of 106,527 participants. The baseline prevalence data showed 16.6% participants with diabetes, 46.5% with hypertension, 44.9% with hypercholesterolaemia and 17.7% with obesity. The follow-up phase commenced in June 2013. This is the most comprehensive and biggest cohort study in Malaysia, and has become a valuable resource for epidemiological and biological research. For information on collaboration and also data access, investigators can contact the project leader at (rahmanj@ppukm.ukm.edu.my).
马来西亚队列研究由马来西亚政府于2005年发起。这种基于人群的队列研究采用自上而下的方法，确保为该项目分配足够的资金，该项目旨在招募10万名年龄在35至70岁之间的个体。参与者从农村和城市地区以及不同社会经济群体中招募。该研究的主要目标是识别风险因素、研究基因-环境相互作用以及发现用于癌症和其他疾病早期检测的生物标志物。在招募时，进行了基于问卷的访谈，进行了生物物理测量，并收集、处理和储存了生物样本。基线调查包括空腹血糖、空腹血脂谱、肾功能指标和全血细胞计数。从2006年4月到2012年9月底，我们共招募了106,527名参与者。基线患病率数据显示，16.6%的参与者患有糖尿病，46.5%患有高血压，44.9%患有高胆固醇血症，17.7%患有肥胖症。随访阶段于2013年6月开始。这是马来西亚最全面、规模最大的队列研究，已成为流行病学和生物学研究的宝贵资源。有关合作信息以及数据访问，请研究者通过(rahmanj@ppukm.ukm.edu.my)联系项目负责人。
