Ruigt G S, Van Proosdij J N, Van Wezenbeek L A
CNS Pharmacology R and D Labs, Organon International, Oss, The Netherlands.
Electroencephalogr Clin Neurophysiol. 1989 Jul;73(1):64-71. doi: 10.1016/0013-4694(89)90020-5.
An automated rat sleep staging system was used to describe sleep-waking behaviour in a large number of rats. The computer scorings were validated by visual analysis of a limited set of data by two human raters and the agreement varied between 82 and 100% for homogeneous segments of the different sleep-waking stages. The automated system proved to be very consistent in view of the small variation in placebo values over 110 experiments. The data show that classification of rat sleep waking behaviour into 6 different stages is both advisable and feasible. The experiments further show that rat age (over a range from 0.5 to 2 years) does not greatly affect rat sleep-waking behaviour.
使用一种自动大鼠睡眠分期系统来描述大量大鼠的睡眠-觉醒行为。通过两名人类评分者对一组有限数据进行视觉分析，验证了计算机评分结果，不同睡眠-觉醒阶段的同质片段的一致性在82%至100%之间。鉴于在110次实验中安慰剂值的变化很小，自动系统被证明非常稳定。数据表明，将大鼠睡眠-觉醒行为分为6个不同阶段是可取且可行的。实验进一步表明，大鼠年龄（在0.5至2岁范围内）对大鼠睡眠-觉醒行为影响不大。
