缓激肽和P物质可增强乙酰胆碱诱导的豚鼠支气管痉挛。
Bradykinin and substance P potentiate acetylcholine-induced bronchospasm in guinea-pig.
作者信息
Omini C, Brunelli G, Hernandez A, Daffonchio L
机构信息
Institute of Pharmacological Sciences, University of Milan, Italy.
出版信息
Eur J Pharmacol. 1989 Apr 12;163(1):195-7. doi: 10.1016/0014-2999(89)90419-6.
The interaction of threshold doses of bradykinin (BK) and substance P (SP) with acetylcholine (ACh)-induced bronchospasm was investigated in anaesthetized guinea-pigs. The two peptides potentiated the ACh-induced bronchospasm, an effect which did not seem to depend on prostaglandin release. On the other hand, vagotomy abolished the capacity of BK and SP to potentiate the ACh-induced bronchospasm. The present data suggest a possible involvement of BK and SP in the genesis of airway hyperreactivity.
在麻醉的豚鼠中研究了缓激肽（BK）和P物质（SP）的阈剂量与乙酰胆碱（ACh）诱导的支气管痉挛之间的相互作用。这两种肽增强了ACh诱导的支气管痉挛，这种作用似乎不依赖于前列腺素的释放。另一方面，迷走神经切断术消除了BK和SP增强ACh诱导的支气管痉挛的能力。目前的数据表明BK和SP可能参与气道高反应性的发生。
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