Department of Medical Microbiology & Parasitology, Ladoke Akintola University of Technology, PMB 4400, Osogbo, Nigeria.
Department of Medical Microbiology & Parasitology, Ladoke Akintola University of Technology, PMB 4400, Osogbo, Nigeria ; Department of Biomedical Science, Ladoke Akintola University of Technology, PMB 4400, Osogbo, Nigeria.
J Trop Med. 2014;2014:161284. doi: 10.1155/2014/161284. Epub 2014 Mar 4.
Malaria and HIV are the two most important health challenges of our time. Haematologic abnormalities are features in Plasmodium falciparum infection, and anaemia is a well-known outcome. The prevalence and haematological impact of P. falciparum parasitaemia were determined among HIV-infected individuals in Nigeria. Parasite detection was carried out using microscopy and Polymerase Chain Reaction (PCR). Haemoglobin concentration was determined using an automated machine while CD4+ T-cells count was analyzed using flow cytometer. Thirty-seven (18.5%) out of the 200 HIV individuals enrolled had malaria parasites detected in their blood. All the positive cases were detected by PCR while only 20 (10%) were detected by thick blood microscopy. The mean haemoglobin concentration and packed cell volume (PCV) of HIV individuals with malaria parasitaemia were lower compared to those without malaria parasitaemia but the difference was not statistically significant. Also no significant difference was observed in malaria positivity in respect to sex and mean CD4+ cell count. The study highlights the effects of P. falciparum parasitaemia on the haematologic and immune components of HIV individuals.
疟疾和艾滋病是我们这个时代最重要的两个健康挑战。血液学异常是恶性疟原虫感染的特征，贫血是一种众所周知的后果。本研究旨在确定尼日利亚艾滋病毒感染者中恶性疟原虫寄生虫血症的流行情况及其对血液学的影响。寄生虫检测采用显微镜检查和聚合酶链反应（PCR）。血红蛋白浓度采用自动化机器检测，CD4+ T 细胞计数采用流式细胞仪分析。200 名入组的艾滋病毒感染者中，有 37 人（18.5%）血液中检测到疟原虫。所有阳性病例均通过 PCR 检测到，而仅通过厚血涂片显微镜检查检测到 20 例（10%）。有疟疾寄生虫血症的艾滋病毒感染者的平均血红蛋白浓度和红细胞压积（PCV）低于无疟疾寄生虫血症的患者，但差异无统计学意义。在疟疾阳性率方面，也未观察到性别和平均 CD4+细胞计数之间存在显著差异。本研究强调了恶性疟原虫寄生虫血症对艾滋病毒感染者血液学和免疫成分的影响。
