Aba Yapo T, Moh Raoul, Ello Nogbou F, Assi Serge-Brice, Ano Ama M, Koffi Brigitte, Mossou Mélaine C, Diallo Zelica, Bissagnene Emmanuel
Department of Infectious and Tropical Diseases, University of Alassane Ouattara, Bouaké, Ivory Coast.
Department of Infectious and Tropical Diseases, University of Felix Houphouet Boigny, Abidjan, Ivory Coast.
Malariaworld J. 2017 Nov 1;8:18. eCollection 2017.
To determine the prevalence and clinical profile of malaria among febrile HIV-infected patients followed up in three HIV clinics in Ivory Coast.
A cross-sectional multicentre study was conducted between 2009 and 2010 in the Pneumology Department of Cocody Teaching Hospital in Abidjan, Medical Esperance Centre and the Regional Hospital in San-Pedro. Patients of all ages presenting with fever (rectal or axillary temperature >37,5°C) or a medical history of fever within 72 hrs prior to consultation were included. Parasitological diagnostic methods used were microscopy by blood smear (BS) for search malaria parasite and parasite density. Haemoglobin levels were assessed to assess anaemia.
Over the study period, 530 people living with HIV consulted for fever. The 476 patients included were predominantly female (n=280, 59%), with a median age of 34 (range 3-74 yrs), a mean of 38 ± 8.3 (SD) yrs, infected with HIV-1 (n=409, 86%), on antiretroviral therapy (n=376, 79%), and cotrimoxazole prophylaxis (n=381, 80%). Only 73 (15%) patients were using LLINs. Malaria prevalence was 10% (n=47). was the only species identified with a mean density of 15 900 trophozoites/μl. Malaria was more common among patients with a CD4 count of <200/mm (p<0.001) neither on cotrimoxazole prophylaxis (p<0.001) nor on antiretroviral therapy (ART) (p<0.001). Uncomplicated malaria accounted for 32 (68%) of the cases. The signs of severe malaria (n=15, 32%,) were dominated by severe anaemia (n= 12, 25.5%).
Our study revealed that malaria prevalence appears to be low in HIV clinics for people living with HIV on HAART and cotrimoxazole prophylaxis. Uncomplicated malaria is predominant when consultation is early. Signs of severe malaria were dominated by severe anaemia.
确定在科特迪瓦的三家艾滋病毒诊所接受随访的发热艾滋病毒感染患者中疟疾的患病率和临床特征。
2009年至2010年在阿比让科科迪教学医院肺病科、医学希望中心和圣佩德罗地区医院进行了一项横断面多中心研究。纳入所有年龄出现发热（直肠或腋窝温度>37.5°C）或在就诊前72小时内有发热病史的患者。所使用的寄生虫学诊断方法是通过血涂片显微镜检查（BS）来寻找疟原虫和寄生虫密度。评估血红蛋白水平以评估贫血情况。
在研究期间，530名艾滋病毒感染者因发热前来就诊。纳入的476名患者以女性为主（n = 280，59%），中位年龄为34岁（范围3 - 74岁），平均年龄为38 ± 8.3（标准差）岁，感染艾滋病毒-1（n = 409，86%），接受抗逆转录病毒治疗（n = 376，79%），并接受复方新诺明预防治疗（n = 381，80%）。只有73名（15%）患者使用长效驱虫蚊帐。疟疾患病率为10%（n = 47）。是唯一鉴定出的物种，平均密度为15900个滋养体/微升。疟疾在CD4细胞计数<200/mm的患者中更常见（p<0.001），既未接受复方新诺明预防治疗（p<0.001）也未接受抗逆转录病毒治疗（ART）（p<0.001）。非复杂性疟疾占病例的32例（68%）。重症疟疾的体征（n = 15，32%）以严重贫血为主（n = 12，25.5%）。
我们的研究表明，在接受高效抗逆转录病毒治疗和复方新诺明预防治疗的艾滋病毒感染者的艾滋病毒诊所中，疟疾患病率似乎较低。早期就诊时非复杂性疟疾占主导。重症疟疾的体征以严重贫血为主。
