一例同时产生甲胎蛋白（AFP）和癌胚抗原（CEA）的胆囊癌。
A case of gallbladder carcinoma producing both alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA).
作者信息
Sugaya Y, Sugaya H, Kuronuma Y, Hisauchi T, Harada T
机构信息
Second Department of Internal Medicine, Dokkyo University School of Medicine, Tochigi, Japan.
出版信息
Gastroenterol Jpn. 1989 Jun;24(3):325-31. doi: 10.1007/BF02774332.
A 73-year-old woman with gallbladder carcinoma infiltrating to the liver presenting high serum values of AFP and CEA was reported. Serum values of AFP and CEA were remarkably high (165,000 ng/ml and 1,070 ng/ml). Immunohistochemically the tumor cells were stained for AFP and CEA by the PAP method. Serum AFP subfraction was analyzed by crossed immunoaffinoelectrophoresis with lentil lectin and concanavalin A, which showed most of the serum AFP bound to both lentil lectin and concanavalin A. As a case of gallbladder carcinoma presenting a high serum value of AFP is rare, it may imply a diagnostic challenge.
报告了一名73岁胆囊癌浸润肝脏的女性，其血清甲胎蛋白（AFP）和癌胚抗原（CEA）值很高。AFP和CEA的血清值显著升高（分别为165,000 ng/ml和1,070 ng/ml）。免疫组织化学检测显示，肿瘤细胞经PAP法检测AFP和CEA呈阳性。采用扁豆凝集素和伴刀豆球蛋白A进行交叉免疫亲和电泳分析血清AFP亚组分，结果显示大部分血清AFP与扁豆凝集素和伴刀豆球蛋白A均结合。由于胆囊癌患者血清AFP值高的情况罕见，这可能意味着诊断上存在挑战。
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