Mkhabela Vuyiswa J, Ray Suprakas Sinha
J Nanosci Nanotechnol. 2014 Jan;14(1):535-45. doi: 10.1166/jnn.2014.9055.
Polycaprolactone is a bioresorbable polymer that has been extensively used in the biomaterials field and a number of drug-delivery systems. The superior rheological and viscoelastic properties of this polymer render it easy to manufacture and manipulate into a large range of medical devices and implants. The advantage of polycaprolactone over its aliphatic counterparts is that it has a long-term degradation period, which provides a good platform for the design and fabrication of implants that require long-term degradation kinetics for example in bone tissue engineering. The incorporation of nanofillers or blending of polycaprolactone with other polymers has yielded a class of hybrid materials with significantly improved physical and chemical properties such as strength, porosity, microstructure, controllable degradation rates, and bioactivity that are important for tissue engineering. This overview highlights the interesting advancements in polycaprolactone polymeric systems that relate to biological and tissue engineering applications, including aspects of technology in fabricating the scaffolds.
聚己内酯是一种可生物降解的聚合物，已在生物材料领域和许多药物递送系统中得到广泛应用。这种聚合物优异的流变学和粘弹性使其易于制造，并能加工成各种医疗设备和植入物。聚己内酯相对于其脂肪族同类物的优势在于它具有较长的降解期，这为例如骨组织工程中需要长期降解动力学的植入物的设计和制造提供了一个良好的平台。加入纳米填料或将聚己内酯与其他聚合物共混，已产生了一类物理和化学性质显著改善的杂化材料，如强度、孔隙率、微观结构、可控降解速率和生物活性，这些对于组织工程很重要。本综述重点介绍了聚己内酯聚合物体系在生物和组织工程应用方面的有趣进展，包括支架制造技术的各个方面。
