Deepa Kannan, Singha Siddhartha, Panda Tapobrata
J Nanosci Nanotechnol. 2014 Jan;14(1):892-904. doi: 10.1166/jnn.2014.8765.
Doxorubicin is one of the most widely administered drugs for treatment of cancer. The shortcomings commonly encountered with this drug are severe cardiotoxicity, narrow therapeutic indices, and the development of multiple drug resistance. Hence, several nanoparticulate drug delivery systems have been designed to overcome these limitations and to improvise the overall therapeutic efficacy of doxorubicin. This review outlines the doxorubicin delivery systems, viz., metals and metal oxide nanoparticles, carbon nanotubes, liposomes, nanoparticles of solid lipid materials, lipid microemulsions, polymer-based nanoparticles, protein-attached nanoparticles, polysaccharide nanoparticles, functional polymers, and nanoparticles of virus.
阿霉素是治疗癌症时使用最广泛的药物之一。这种药物常见的缺点是严重的心脏毒性、狭窄的治疗指数以及多重耐药性的产生。因此，人们设计了几种纳米颗粒药物递送系统来克服这些局限性，并提高阿霉素的整体治疗效果。本综述概述了阿霉素递送系统，即金属和金属氧化物纳米颗粒、碳纳米管、脂质体、固体脂质材料纳米颗粒、脂质微乳、聚合物基纳米颗粒、蛋白质附着纳米颗粒、多糖纳米颗粒、功能聚合物和病毒纳米颗粒。
