Tambuyzer Tim, De Waele Tine, Chiers Koen, Berckmans Daniel, Goddeeris Bruno M, Aerts Jean-Marie
Division Measure, Model & Manage Bioresponses, Department of Biosystems, KU Leuven, Kasteelpark Arenberg 30, B-3001 Leuven, Belgium.
Laboratory of Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium.
Res Vet Sci. 2014 Jun;96(3):460-3. doi: 10.1016/j.rvsc.2014.03.014. Epub 2014 Mar 28.
Static interleukin-6 (IL-6) levels of pigs contain considerable individual differences, which obstruct the practical use of IL-6 for disease monitoring purposes. It was hypothesised that interleukin-6 (IL-6) dynamics could be used to quantify these individual differences and carries critical information of the individual pig infection status. Time series of IL-6 responses in 25 pigs were analysed before and after infection by Actinobacillus pleuropneumoniae. The results indicated that amplitude increases of IL-6 fluctuations of individual pigs rather than static IL-6 values should be used as indicator of the infection state. This study shows the added value for IL-6 time series analyses of individual pigs. These results are a first step towards the development of objective individualised methods for monitoring and early detection of sepsis and inflammation processes in pigs by integrating animal response dynamics.
猪的静态白细胞介素-6（IL-6）水平存在相当大的个体差异，这阻碍了将IL-6实际用于疾病监测目的。研究假设白细胞介素-6（IL-6）动态变化可用于量化这些个体差异，并携带个体猪感染状态的关键信息。对25头猪感染胸膜肺炎放线杆菌前后的IL-6反应时间序列进行了分析。结果表明，应将个体猪IL-6波动的幅度增加而非静态IL-6值用作感染状态的指标。本研究显示了对个体猪进行IL-6时间序列分析的附加价值。这些结果是朝着通过整合动物反应动态来开发客观个体化方法以监测和早期检测猪败血症和炎症过程迈出的第一步。
