• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

“肥胖悖论”误解了整个生命周期中最佳体重的生物学原理。

'Obesity paradox' misunderstands the biology of optimal weight throughout the life cycle.

作者信息

Dixon J B, Egger G J, Finkelstein E A, Kral J G, Lambert G W

机构信息

Baker IDI Heart & Diabetes Institute, Melbourne, Victoria, Australia.

School of Health & Human Sciences, Southern Cross University, Lismore, Balgowlah NSW, Australia.

出版信息

Int J Obes (Lond). 2015 Jan;39(1):82-4. doi: 10.1038/ijo.2014.59. Epub 2014 Apr 15.

DOI:10.1038/ijo.2014.59
PMID:24732145
Abstract

The 'obesity paradox' refers to observations that run counter to the thesis that normal weight (BMI 18.5-24.9 g/m(2)) provides the lowest mortality and higher weight is associated with greater mortality. We argue that the weight of lowest mortality is influenced by aging and chronic disease, with mortality advantage extending into the overweight and even class I obese ranges under some circumstances. A focus on quality nutrition, physical activity, fitness, and maintaining function in these weight ranges may be preferable to a focus on intentional weight loss, which has uncertain effects. The 'obesity paradox' is no 'paradox' if one defines and interprets 'ideal' weight appropriately.

摘要

“肥胖悖论”指的是一些与正常体重(体重指数18.5 - 24.9 g/m²)死亡率最低且体重越高死亡率越高这一论点相悖的观察结果。我们认为,最低死亡率的体重受到衰老和慢性病的影响,在某些情况下,死亡率优势会延伸到超重甚至I级肥胖范围。关注这些体重范围内的优质营养、体育活动、健康状况以及维持身体功能,可能比关注效果不确定的刻意减肥更为可取。如果能恰当地定义和解释“理想”体重,“肥胖悖论”就并非“悖论”。

相似文献

1
'Obesity paradox' misunderstands the biology of optimal weight throughout the life cycle.“肥胖悖论”误解了整个生命周期中最佳体重的生物学原理。
Int J Obes (Lond). 2015 Jan;39(1):82-4. doi: 10.1038/ijo.2014.59. Epub 2014 Apr 15.
2
Complex interaction of obesity, intentional weight loss and heart failure: a systematic review and meta-analysis.肥胖、有意减重与心力衰竭的复杂相互作用:系统评价与荟萃分析。
Heart. 2020 Jan;106(1):58-68. doi: 10.1136/heartjnl-2019-314770. Epub 2019 Sep 17.
3
Obesity paradox in elderly patients with cardiovascular diseases.老年心血管病患者的肥胖悖论。
Int J Cardiol. 2012 Feb 23;155(1):56-65. doi: 10.1016/j.ijcard.2011.01.076. Epub 2011 Feb 22.
4
The obesity paradox, weight loss, and coronary disease.肥胖悖论、体重减轻与冠心病。
Am J Med. 2009 Dec;122(12):1106-14. doi: 10.1016/j.amjmed.2009.06.006. Epub 2009 Aug 13.
5
Obesity paradox in group 1 pulmonary hypertension: analysis of the NIH-Pulmonary Hypertension registry.1型肺动脉高压中的肥胖悖论:美国国立卫生研究院肺动脉高压注册研究分析
Int J Obes (Lond). 2017 Aug;41(8):1164-1168. doi: 10.1038/ijo.2017.45. Epub 2017 Feb 17.
6
From the BMI paradox to the obesity paradox: the obesity-mortality association in coronary heart disease.从 BMI 悖论到肥胖悖论:冠心病中的肥胖与死亡率关联。
Obes Rev. 2016 Oct;17(10):989-1000. doi: 10.1111/obr.12440. Epub 2016 Jul 13.
7
Obesity paradox in different populations: evidence and controversies.不同人群中的肥胖悖论:证据与争议
Future Cardiol. 2014 Jan;10(1):81-91. doi: 10.2217/fca.13.84.
8
An Overview and Update on Obesity and the Obesity Paradox in Cardiovascular Diseases.肥胖与心血管疾病中肥胖悖论的概述及最新进展
Prog Cardiovasc Dis. 2018 Jul-Aug;61(2):142-150. doi: 10.1016/j.pcad.2018.07.003. Epub 2018 Jul 5.
9
The interaction of exercise ability and body mass index upon long-term outcomes among patients undergoing stress-rest perfusion single-photon emission computed tomography imaging.运动能力与身体质量指数在应激-静息灌注单光子发射计算机断层扫描成像患者的长期预后中的相互作用。
Am Heart J. 2013 Jul;166(1):127-33. doi: 10.1016/j.ahj.2013.03.027. Epub 2013 May 2.
10
Fitness vs. fatness on all-cause mortality: a meta-analysis.体能与肥胖对全因死亡率的影响:一项荟萃分析。
Prog Cardiovasc Dis. 2014 Jan-Feb;56(4):382-90. doi: 10.1016/j.pcad.2013.09.002. Epub 2013 Oct 11.

引用本文的文献

1
Editorial: Obesity across the life course.社论:一生的肥胖问题。
Front Public Health. 2025 Jun 13;13:1591010. doi: 10.3389/fpubh.2025.1591010. eCollection 2025.
2
Physical Activity, Cardiorespiratory Fitness, and the Obesity Paradox with Consideration for Racial and/or Ethnic Differences: A Broad Review and Call to Action.体育活动、心肺适能与肥胖悖论及种族和/或民族差异考量:全面综述与行动呼吁
Rev Cardiovasc Med. 2024 Aug 19;25(8):291. doi: 10.31083/j.rcm2508291. eCollection 2024 Aug.
3
BMI trajectories, morbidity, and mortality in England: a two-step approach to estimating consequences of changes in BMI.

本文引用的文献

1
Obesity and mortality risk: new findings from body mass index trajectories.肥胖与死亡率风险:体重指数轨迹的新发现。
Am J Epidemiol. 2013 Dec 1;178(11):1591-9. doi: 10.1093/aje/kwt179. Epub 2013 Sep 7.
2
The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis.Apelin 受体 APJ:从孤儿受体到维持内环境稳定的多功能调节剂的历程。
J Endocrinol. 2013 Sep 11;219(1):R13-35. doi: 10.1530/JOE-13-0227. Print 2013 Oct.
3
Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes.2 型糖尿病强化生活方式干预的心血管效应。
英国的 BMI 轨迹、发病率和死亡率:一种估计 BMI 变化后果的两步法。
Obesity (Silver Spring). 2022 Sep;30(9):1898-1907. doi: 10.1002/oby.23510. Epub 2022 Aug 3.
4
Impact of BMI on Long-Term Outcomes in Patients with ST-Segment Elevation Myocardial Infarction after Primary Percutaneous Coronary Intervention.体重指数对经皮冠状动脉介入治疗后 ST 段抬高型心肌梗死患者长期结局的影响。
Int J Clin Pract. 2022 Jan 31;2022:6210204. doi: 10.1155/2022/6210204. eCollection 2022.
5
Relationship of body fat and left ventricular hypertrophy with the risk of all-cause death in patients with coronary artery disease.冠心病患者体内脂肪及左心室肥厚与全因死亡风险的关系。
J Geriatr Cardiol. 2022 Mar 28;19(3):218-226. doi: 10.11909/j.issn.1671-5411.2022.03.002.
6
Bodyweight change and cognitive performance in the older population.老年人群的体重变化与认知表现
PLoS One. 2021 Apr 21;16(4):e0249651. doi: 10.1371/journal.pone.0249651. eCollection 2021.
7
Epidemiology and outcomes of obese critically ill patients in Australia and New Zealand.澳大利亚和新西兰肥胖危重症患者的流行病学和转归。
Crit Care Resusc. 2020 Mar;22(1):35-44. doi: 10.51893/2020.1.oa4.
8
The genetics of human ageing.人类衰老的遗传学。
Nat Rev Genet. 2020 Feb;21(2):88-101. doi: 10.1038/s41576-019-0183-6. Epub 2019 Nov 5.
9
The Role of Adipose Tissue and Adipokines in Sepsis: Inflammatory and Metabolic Considerations, and the Obesity Paradox.脂肪组织和脂肪因子在脓毒症中的作用:炎症和代谢的考虑因素,以及肥胖悖论。
Curr Obes Rep. 2019 Dec;8(4):434-457. doi: 10.1007/s13679-019-00360-2.
10
Determining the Joint Effect of Obesity and Diabetes on All-Cause Mortality and Cardiovascular-Related Mortality following an Ischemic Stroke.确定肥胖与糖尿病对缺血性中风后全因死亡率和心血管相关死亡率的联合影响。
Stroke Res Treat. 2018 Aug 9;2018:4812712. doi: 10.1155/2018/4812712. eCollection 2018.
N Engl J Med. 2013 Jul 11;369(2):145-54. doi: 10.1056/NEJMoa1212914. Epub 2013 Jun 24.
4
Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis.采用标准体重指数类别评估全因死亡率与超重和肥胖的关联:系统评价和荟萃分析。
JAMA. 2013 Jan 2;309(1):71-82. doi: 10.1001/jama.2012.113905.
5
Association of weight status with mortality in adults with incident diabetes.体重状况与新发糖尿病成人死亡率的相关性。
JAMA. 2012 Aug 8;308(6):581-90. doi: 10.1001/jama.2012.9282.
6
Inverse relation of body weight and weight change with mortality and morbidity in patients with type 2 diabetes and cardiovascular co-morbidity: an analysis of the PROactive study population.2 型糖尿病合并心血管合并症患者的体重和体重变化与死亡率和发病率的反比关系:对 PROactive 研究人群的分析。
Int J Cardiol. 2012 Dec 15;162(1):20-6. doi: 10.1016/j.ijcard.2011.09.039. Epub 2011 Oct 29.
7
The association between obesity and mortality in the elderly differs by serum concentrations of persistent organic pollutants: a possible explanation for the obesity paradox.肥胖与老年人死亡率之间的关联因血清中持久性有机污染物的浓度而有所不同:肥胖悖论的一种可能解释。
Int J Obes (Lond). 2012 Sep;36(9):1170-5. doi: 10.1038/ijo.2011.187. Epub 2011 Sep 27.
8
The obesity paradox and weight loss.肥胖悖论与体重减轻。
Am J Med. 2011 Oct;124(10):924-30. doi: 10.1016/j.amjmed.2011.04.018. Epub 2011 Jul 26.
9
Survival among high-risk patients after bariatric surgery.高危患者在接受减重手术后的存活率。
JAMA. 2011 Jun 15;305(23):2419-26. doi: 10.1001/jama.2011.817. Epub 2011 Jun 12.
10
Body mass index and physical activity in relation to the incidence of hip fracture in postmenopausal women.体重指数和身体活动与绝经后妇女髋部骨折发生率的关系。
J Bone Miner Res. 2011 Jun;26(6):1330-8. doi: 10.1002/jbmr.315.