Dahlmann N, Hartlapp J H
Institut für Klinische Biochemie, Universität Bonn.
Klin Wochenschr. 1989 Apr 3;67(7):408-12. doi: 10.1007/BF01711270.
Because of spuriously elevated alpha-fetoprotein levels, a course of polychemotherapy was given to a patient. We purified and identified the serum factor responsible for falsely high AFP levels as an IgG directed against mouse IgG. On gel filtration it behaves differently from true AFP, exhibiting a molecular weight of around 150,000. Chromatography on 'Protein A-Sepharose' revealed properties indistinguishable from those of IgG. The patient had never been treated with mouse antibodies, neither for diagnostic nor therapeutic purposes and he had had no contact with animals professionally.
由于甲胎蛋白水平假性升高，对一名患者进行了多药化疗疗程。我们纯化并鉴定出导致甲胎蛋白水平假性升高的血清因子为一种抗小鼠IgG的IgG。在凝胶过滤中，它的行为与真正的甲胎蛋白不同，分子量约为150,000。在“蛋白A-琼脂糖”上的色谱分析显示其性质与IgG无法区分。该患者从未接受过小鼠抗体治疗，无论是用于诊断还是治疗目的，并且他在职业上没有与动物接触过。
