Takenaka Mizuki, Verbitskiy Daniil, Zehrmann Anja, Härtel Barbara, Bayer-Császár Eszter, Glass Franziska, Brennicke Axel
Molekulare Botanik, Universität Ulm, 89069 Ulm, Germany.
Molekulare Botanik, Universität Ulm, 89069 Ulm, Germany.
Mitochondrion. 2014 Nov;19 Pt B:191-7. doi: 10.1016/j.mito.2014.04.005. Epub 2014 Apr 13.
RNA editing changes several hundred cytidines to uridines in the mRNAs of mitochondria in flowering plants. The target cytidines are identified by a subtype of PPR proteins characterized by tandem modules which each binds with a specific upstream nucleotide. Recent progress in correlating repeat structures with nucleotide identities allows to predict and identify target sites in mitochondrial RNAs. Additional proteins have been found to play a role in RNA editing; their precise function still needs to be elucidated. The enzymatic activity performing the C to U reaction may reside in the C-terminal DYW extensions of the PPR proteins; however, this still needs to be proven. Here we update recent progress in understanding RNA editing in flowering plant mitochondria.
在开花植物中，RNA编辑可将线粒体mRNA中的数百个胞嘧啶转变为尿嘧啶。目标胞嘧啶由PPR蛋白的一个亚型识别，该亚型的特征是具有串联模块，每个模块与一个特定的上游核苷酸结合。将重复结构与核苷酸身份相关联的最新进展使得预测和识别线粒体RNA中的靶位点成为可能。已发现其他蛋白质在RNA编辑中发挥作用；它们的确切功能仍有待阐明。执行C到U反应的酶活性可能存在于PPR蛋白的C末端DYW延伸区；然而，这仍有待证实。在此，我们更新了对开花植物线粒体RNA编辑的最新认识进展。
