Neurophysics Group, Department of Neurology, Campus Benjamin Franklin, Charité, University Medicine, Hindenburgdamm 30, 12203 Berlin, Germany; Bernstein Center for Computational Neuroscience, Philippstraße 12, 10115 Berlin, Germany.
Neurophysics Group, Department of Neurology, Campus Benjamin Franklin, Charité, University Medicine, Hindenburgdamm 30, 12203 Berlin, Germany.
Neuroimage. 2014 Aug 15;97:71-80. doi: 10.1016/j.neuroimage.2014.04.008. Epub 2014 Apr 13.
Previous studies demonstrated the presence of Monochromatic Ultra-Slow Oscillations (MUSO) in human EEG. In the present study we explored the biological origin of MUSO by simultaneous recordings of EEG, Near-Infrared Spectroscopy (NIRS), arterial blood pressure, respiration and Laser Doppler flowmetry. We used a head-up tilt test in order to check whether MUSO might relate to Mayer waves in arterial blood pressure, known to be enhanced by the tilting procedure. MUSO were detected in 8 out of 10 subjects during rest and showed a striking monochromatic spectrum (0.07-0.14 Hz). The spatial topography of MUSO was complex, showing multiple foci variable across subjects. While the head-up tilt test increased the relative power of Mayer waves, it had no effect on MUSO. On the other hand, the relative spectral power of 0.1 Hz oscillations in EEG, NIRS and blood pressure signals were positively correlated across subjects in the tilted condition. Eight subjects showed a coherence between MUSO and NIRS/arterial blood pressure. Moreover, MUSO at different electrode sites demonstrated coherence not reducible to volume conduction, thus indicating that MUSO are unlikely to be generated by one source. We related our experimental findings to known biological phenomena being generated at about 0.1 Hz, i.e.: arterial blood pressure, cerebral and skin vasomotion, respiration and neuronal activity. While no definite conclusion can yet be drawn as to an exact physiological mechanism of MUSO, we suggest that these oscillations might be of a rather extraneuronal origin reflecting cerebral vasomotion.
先前的研究表明，人类脑电图中存在单色调超慢振荡（MUSO）。在本研究中，我们通过同时记录脑电图、近红外光谱（NIRS）、动脉血压、呼吸和激光多普勒流量来探索 MUSO 的生物学起源。我们使用头高位倾斜试验来检查 MUSO 是否与动脉血压中的 Mayer 波有关，已知倾斜过程会增强 Mayer 波。在休息时，10 名受试者中有 8 名检测到 MUSO，并显示出明显的单色调谱（0.07-0.14 Hz）。MUSO 的空间拓扑结构复杂，在不同受试者之间显示出多个可变焦点。虽然头高位倾斜试验增加了 Mayer 波的相对功率，但对 MUSO 没有影响。另一方面，在倾斜状态下，脑电图、NIRS 和血压信号中 0.1 Hz 振荡的相对谱功率在受试者之间呈正相关。在 8 名受试者中，MUSO 与 NIRS/动脉血压之间存在相干性。此外，MUSO 在不同电极部位的相干性不能归结为容积传导，这表明 MUSO 不太可能由一个源产生。我们将我们的实验结果与已知的以 0.1 Hz 左右产生的生物学现象联系起来，即：动脉血压、脑和皮肤血管运动、呼吸和神经元活动。虽然还不能确定 MUSO 的确切生理机制，但我们认为这些振荡可能是一种相当非神经元起源的脑血管运动的反映。
