Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia UdeA, Medellín, Colombia.
J Acquir Immune Defic Syndr. 2014 Aug 1;66(4):365-9. doi: 10.1097/QAI.0000000000000162.
HIV replication control is important to reduce AIDS progression. We determined frequency and activation status of immune cells in spontaneous HIV controllers vs. individuals with highly active antiretroviral therapy (HAART)-controlled viral load. HIV controllers exhibited significantly higher frequency of CD4 T cells and myeloid dendritic cells compared with HAART-controlled viral load. Additionally, HIV controllers have a significantly lower percentage of cells expressing activation markers on CD4 and CD8 T cells, myeloid dendritic cells, and natural killer cells. These findings suggest that during HIV infection, conservation of a normal frequency and physiological range of immune activation is associated with spontaneous, but not HAART-induced, control of viral replication.
HIV 复制的控制对于减少艾滋病的进展非常重要。我们确定了自发 HIV 控制者与接受高效抗逆转录病毒治疗（HAART）控制病毒载量的个体之间免疫细胞的频率和激活状态。与 HAART 控制病毒载量的个体相比，HIV 控制者的 CD4 T 细胞和髓样树突状细胞的频率明显更高。此外，HIV 控制者的 CD4 和 CD8 T 细胞、髓样树突状细胞和自然杀伤细胞上表达激活标志物的细胞比例明显更低。这些发现表明，在 HIV 感染期间，免疫激活的正常频率和生理范围的保持与病毒复制的自发性控制有关，而与 HAART 诱导的控制无关。
