Benito Jose M, Lopez Mariola, Lozano Sara, Ballesteros Celia, Capa Laura, Martinez Pilar, Gonzalez-Lahoz Juan, Soriano Vincent
Service of Infectious Diseases, Hospital Carlos III, Madrid, Spain.
J Infect Dis. 2005 Dec 15;192(12):2142-6. doi: 10.1086/498168.
CD38 expression on CD8(+) T cells was longitudinally assessed in 31 human immunodeficiency virus (HIV)-infected persons with undetectable plasma viremia who had undergone highly active antiretroviral therapy (HAART) for 12 months and were followed for a mean of 30 months thereafter. Overall, CD4(+)T cell counts increased during follow-up, whereas CD38 expression remained stable. However, a subset of patients showed declines in CD38 expression, and, conversely, another subset showed increases in CD38 expression. No association could be found between long-term gains in CD4(+) T cells and evolution of CD38 expression. Thus, activation of CD8(+) T cells does not seem to be associated with the extent of CD4(+) T cell recovery beyond the first year of successful HAART.
对31名接受高效抗逆转录病毒疗法（HAART）12个月且血浆病毒血症检测不到、随后平均随访30个月的人类免疫缺陷病毒（HIV）感染者的CD8(+) T细胞上的CD38表达进行了纵向评估。总体而言，随访期间CD4(+)T细胞计数增加，而CD38表达保持稳定。然而，一部分患者的CD38表达下降，相反，另一部分患者的CD38表达增加。在CD4(+) T细胞的长期增加与CD38表达的演变之间未发现关联。因此，在成功进行HAART的第一年之后，CD8(+) T细胞的激活似乎与CD4(+) T细胞恢复的程度无关。
