（邻炔基苯基）（甲氧基甲基）硫醚与钯（II）-双恶唑啉催化剂的环化-羰基化-环化偶联反应
A cyclization-carbonylation-cyclization coupling reaction of (ortho-alkynyl phenyl) (methoxymethyl) sulfides with the palladium(II)-bisoxazoline catalyst.
作者信息
Jiang Yiyun, Kusakabe Taichi, Takahashi Keisuke, Kato Keisuke
机构信息
Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan.
出版信息
Org Biomol Chem. 2014 Jun 7;12(21):3380-5. doi: 10.1039/c4ob00299g. Epub 2014 Apr 15.
PMID:24733174
Abstract
A cyclization-carbonylation-cyclization coupling reaction (CCC-coupling reaction) of (o-alkynylphenyl) (methoxymethyl) sulfides, catalyzed by (box)Pd(II) complexes, afforded symmetrical ketones bearing two benzo[b]thiophene groups in good to excellent yields. This method is applicable to a broad range of substrates.
摘要
在（box）Pd（II）配合物催化下，（邻炔基苯基）（甲氧基甲基）硫醚的环化-羰基化-环化偶联反应（CCC偶联反应）能以良好至优异的产率得到带有两个苯并[b]噻吩基团的对称酮。该方法适用于多种底物。
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