钯催化的 C-S 偶联反应：硫醚、苯并[b]噻吩和噻吩并[3,2-b]噻吩的合成途径。
Palladium-catalyzed C-S coupling: access to thioethers, benzo[b]thiophenes, and thieno[3,2-b]thiophenes.
机构信息
Institute of Organic Chemistry, Karlsruhe Institute of Technology, Fritz-Haber-Weg 6, D-76131 Karlsruhe, Germany.
出版信息
Org Lett. 2011 Aug 5;13(15):4100-3. doi: 10.1021/ol2016093. Epub 2011 Jul 6.
PMID:21732682
Abstract
The first C-S bond formation/cross-coupling/cyclization domino reaction using thiourea as a cheap and easy to handle dihydrosulfide surrogate has been developed. Structurally important biarylthioether, benzo[b]thiophenes, and thieno[3,2-b]thiophene scaffolds are provided in high yield.
摘要
首次开发了以硫脲作为廉价易得的二氢硫化物替代物的 C-S 键形成/交叉偶联/环化串联反应。以高产率提供了结构重要的联芳基硫醚、苯并[b]噻吩和噻吩[3,2-b]噻吩骨架。
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