Bonda David J, Wang Xinglong, Lee Hyoung-Gon, Smith Mark A, Perry George, Zhu Xiongwei
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
Neurosci Bull. 2014 Apr;30(2):243-52. doi: 10.1007/s12264-013-1424-x. Epub 2014 Apr 15.
Considerable debate and controversy surround the cause(s) of Alzheimer's disease (AD). To date, several theories have gained notoriety, however none is universally accepted. In this review, we provide evidence for the oxidative stress-induced AD cascade that posits aged mitochondria as the critical origin of neurodegeneration in AD.
围绕阿尔茨海默病（AD）的病因存在着大量的争论和争议。迄今为止，有几种理论声名远扬，但没有一种被普遍接受。在本综述中，我们提供了氧化应激诱导的AD级联反应的证据，该级联反应认为老化的线粒体是AD神经退行性变的关键起源。
