Ozekes Serhat, Erguzel Turker, Sayar Gokben Hizli, Tarhan Nevzat
Department of Computer Engineering, Faculty of Engineering and Natural Sciences, Uskudar University, Istanbul, Turkey
Department of Computer Engineering, Faculty of Engineering and Natural Sciences, Uskudar University, Istanbul, Turkey.
Clin EEG Neurosci. 2014 Oct;45(4):257-261. doi: 10.1177/1550059413515656. Epub 2014 Apr 14.
Repetitive transcranial magnetic stimulation (rTMS) is a treatment procedure that uses magnetic fields to stimulate nerve cells in the brain, and is associated with significant improvements in clinical symptoms of major depressive disorder (MDD). The effect of rTMS treatment on the brain can be evaluated by cordance, a quantitative electroencephalography (QEEG) method that extracts information from absolute and relative power of EEG spectra. In this study, to analyze brain functional changes, pre- and post-rTMS, QEEG data were collected from 6 frontal electrodes (Fp1, Fp2, F3, F4, F7, and F8) in 2 slow bands (delta and theta) for 55 MDD subjects. To examine brain changes, cordance scores were determined, using repeated-measures analysis of variance (ANOVA). High-frequency rTMS was associated with cordance decrease in left frontal and right prefrontal regions in both delta and theta for nonresponders; it was associated with cordance increase in all right and left frontal electrodes, except F8, for responders.
重复经颅磁刺激（rTMS）是一种利用磁场刺激大脑神经细胞的治疗方法，与重度抑郁症（MDD）的临床症状显著改善相关。rTMS治疗对大脑的影响可以通过协调性分析来评估，这是一种定量脑电图（QEEG）方法，可从脑电图频谱的绝对功率和相对功率中提取信息。在本研究中，为了分析rTMS治疗前后的脑功能变化，从55名MDD受试者的6个额部电极（Fp1、Fp2、F3、F4、F7和F8）在2个慢波频段（δ波和θ波）收集了QEEG数据。为了检查大脑变化，使用重复测量方差分析（ANOVA）确定协调性得分。对于无反应者，高频rTMS与左额叶和右前额叶区域在δ波和θ波中的协调性降低相关；对于有反应者，除F8外，所有左右额部电极的协调性均增加。
