Trujillo-de Santiago Grissel, Patricio Sáenz-Collins Carlos, García-Arellano Lizette, Moisés Álvarez Mario
FEMSA-Biotechnology Center, Monterrey Tech (Centro de Biotecnología-FEMSA, Tecnológico de Monterrey). Ave. Eugenio Garza Sada 2501 sur. Col. Tecnológico, Monterrey, Nuevo León, México.C.P.64849.
Iran J Pharm Res. 2014 Winter;13(1):39-48.
Contraceptive patches have become a frequently used contraceptive method. We present a mathematical model that describes the serum concentration profiles of Norelgestromin (NGMN) and Ethinylestradiol (EE) released from the contraceptive patch Ortho Evra(®). We propose a simple one-compartment model based on pharmacokinetics data reported in previous studies. The model assumes a time-dependent release rate and a first order elimination rate for each of the active ingredients contained in the patch. The model was applied to noncompliance scenarios, such as total and partial detachment of the patch or prolonged use without patch replacement. The proposed model adequately describes the clinically observed evolution of NGMN and EE in serum. Predictions from the model were successfully validated using reported experimental data of serum concentrations of NGMN and EE. This simple model can be a valuable tool to predict pharmacokinetic profiles in diverse scenarios such us non-compliance situations. Alternatively, the model can be conveniently adapted to anticipate the effect of variations on patch characteristics such as differences in contact area, doses, materials, among others.
避孕贴片已成为一种常用的避孕方法。我们提出了一个数学模型，该模型描述了从避孕贴片Ortho Evra（®）释放的诺孕酯（NGMN）和炔雌醇（EE）的血清浓度曲线。我们基于先前研究报告的药代动力学数据提出了一个简单的单室模型。该模型假设贴片中所含每种活性成分的释放速率随时间变化且消除速率为一级。该模型被应用于不依从的情况，例如贴片完全或部分脱落，或延长使用而不更换贴片。所提出的模型充分描述了临床上观察到的血清中NGMN和EE的变化情况。使用报告的NGMN和EE血清浓度实验数据成功验证了该模型的预测结果。这个简单的模型可以成为预测各种情况下药代动力学曲线的有价值工具，比如不依从情况。另外，该模型可以方便地进行调整，以预测贴片特性变化的影响，如接触面积、剂量、材料等方面的差异。
