Baniasadi Shadi, Habibi Maryam, Haghgoo Roodabeh, Karimi Gamishan Masoumeh, Dabaghzadeh Fatemeh, Farasatinasab Maryam, Farsaei Shadi, Gharekhani Afshin, Kafi Hamidreza, Karimzadeh Iman, Kharazmkia Ali, Najmeddin Farhad, Nikvarz Naemeh, Oghazian Mohammad Bagher, Rezaee Haleh, Sadeghi Kourosh, Tafazzoli Ali, Shahsavari Nahid, Fahimi Fanak
Virology Research Center, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Chronic Respiratory Disease Research Center, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iran J Pharm Res. 2014 Winter;13(1):291-7.
Detection of adverse drug reactions (ADRs) in hospitals provides an important measure of the burden of drug related morbidity on the healthcare system. Spontaneous reporting of ADRs is scare and several obstacles to such reporting have been identified formerly. This study aimed to determine the role of clinical pharmacy residents in ADR reporting within a hospital setting. Clinical pharmacy residents were trained to report all suspected ADRs through ADR-reporting yellow cards. The incidence, pattern, seriousness, and preventability of the reported ADRs were analyzed. During the period of 12 months, for 8559 patients, 202 ADR reports were received. The most frequently reported reactions were due to anti-infective agents (38.38%). Rifampin accounted for the highest number of the reported ADRs among anti-infective agents. The gastro-intestinal system was the most frequently affected system (21.56%) of all reactions. Fifty four of the ADRs were reported as serious reactions. Eighteen of the ADRs were classified as preventable. Clinical pharmacy residents' involvement in the ADR reporting program could improve the ADR reporting system.
医院中药物不良反应（ADR）的监测为衡量医疗系统中与药物相关的发病负担提供了一项重要指标。ADR的自发报告较为少见，此前已发现此类报告存在若干障碍。本研究旨在确定临床药学住院医师在医院环境下ADR报告中的作用。对临床药学住院医师进行培训，使其通过ADR报告黄卡报告所有疑似ADR。分析所报告ADR的发生率、类型、严重程度及可预防性。在12个月期间，共收到8559例患者的202份ADR报告。报告最多的不良反应是由抗感染药物引起的（38.38%）。在抗感染药物中，利福平报告的ADR数量最多。在所有反应中，胃肠道系统是受影响最频繁的系统（21.56%）。54例ADR被报告为严重反应。18例ADR被归类为可预防的。临床药学住院医师参与ADR报告项目可改善ADR报告系统。
