使用手性二胺配位的 Sn(II)三氟甲磺酸酯的不对称 Mukaiyama 羟醛反应：发展与在天然产物合成中的应用。
Asymmetric Mukaiyama aldol reactions using chiral diamine-coordinated Sn(II) triflate: development and application to natural product synthesis.
出版信息
Chem Rec. 2014 Feb;14(1):144-83. doi: 10.1002/tcr.201300022.
PMID:24734309
Abstract
In 1989, the asymmetric Mukaiyama aldol reaction mediated by a Lewis acid consisting of a chiral diamine and Sn(II) triflate was reported. The asymmetric Mukaiyama aldol reaction is now widely used as a versatile tool for the construction of highly advanced, multifunctionalized molecules. In this Personal Account, the history of the development of this powerful methodology and the application of the asymmetric Mukaiyama aldol reaction in the synthesis of natural products are reviewed.
摘要
1989 年，报道了由手性二胺和三氟甲磺酸锡(II)组成的路易斯酸介导的不对称 Mukaiyama 羟醛反应。不对称 Mukaiyama 羟醛反应现在被广泛用作构建高度先进的多功能分子的通用工具。在这篇个人述评中，回顾了这种强大方法学的发展历史以及在天然产物合成中不对称 Mukaiyama 羟醛反应的应用。
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