Solomon K D, Gwin T D, O'Morchoe D J, Tetz M R, Hansen S O, Sugita A, Imkamp E M, Apple D J
Department of Ophthalmology, Medical University of South Carolina, Charleston 29401.
Ophthalmology. 1989 May;96(5):591-7. doi: 10.1016/s0161-6420(89)32854-5.
In an experimental study using albino Rex rabbits, the intercapsular cataract extraction (ICCE) technique was performed in 20 eyes with a small anterior capsulotomy. A large, can opener capsulotomy was performed in another 20 eyes, and 10 unoperated eyes served as controls. Endothelial cell loss was determined by vital staining with Trypan blue and Alizarin red S stains. Average endothelial cell loss with the ICCE technique was 1.2%; with the can opener technique, the average cell loss was 6.6%. This difference was statistically significant (P less than 0.01). The percentage of endothelial cell loss in the control eyes was 0.5. A positive correlation between endothelial cell loss related to phacoemulsification time and/or the amount of irrigating fluid used existed for the can opener group only (P less than 0.01). These results demonstrate that the presence of an almost intact anterior lens capsule during removal of lens substance is protective to the corneal endothelium.
在一项使用白化病 Rex 兔的实验研究中，对 20 只眼睛进行了小切口晶状体囊内摘除术（ICCE），并做了小的前囊切开。对另外 20 只眼睛进行了大的、开罐器式囊切开术，10 只未手术的眼睛作为对照。通过台盼蓝和茜素红 S 染色进行活体染色来确定内皮细胞损失。ICCE 技术导致的平均内皮细胞损失为 1.2%；采用开罐器技术时，平均细胞损失为 6.6%。这种差异具有统计学意义（P 小于 0.01）。对照眼中内皮细胞损失的百分比为 0.5。仅在开罐器组中，内皮细胞损失与超声乳化时间和/或所用冲洗液量之间存在正相关（P 小于 0.01）。这些结果表明，在晶状体物质摘除过程中存在几乎完整的晶状体前囊对角膜内皮具有保护作用。
