Dada Vijay K, Sharma Namrata, Sudan Rajeev, Sethi Harinder, Dada Tanuj, Pangtey Mayank S
Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
J Cataract Refract Surg. 2004 Feb;30(2):326-33. doi: 10.1016/S0886-3350(03)00573-X.
To compare the safety and efficacy of trypan blue 0.1%, gentian violet 0.001%, indocyanine green 0.5% (ICG), fluorescein 2%, and the patient's autologous blood for anterior capsule staining in cases of white cataract.
Rajendra Prasad Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Fifty eyes of 50 patients with age-related white cataract had anterior capsule staining with trypan blue, ICG, or gentian violet under an air bubble or subcapsularly with fluorescein or autologous blood followed by phacoemulsification with foldable intraocular lens implantation. Each stain was used in 10 eyes. The ease of creating a continuous curvilinear capsulorhexis (CCC) and the complications during the surgery were noted. Postoperative examinations at 6 hours, 1 day, 1 week, and 1 month included slitlamp microscopy, uncorrected visual acuity, and best corrected visual acuity (BCVA). The staining patterns on the anterior capsule, side port, corneal tunnel, and anterior cortex were assessed intraoperatively and within 6 hours and at 1 day. The intraocular pressure (IOP) was assessed at 1 day; pachymetry, at 1 day and 1 month; and the endothelial cell count, at 1 month.
The surgeon had best visualization during the anterior capsulorhexis with trypan blue, ICG, and gentian violet, and a complete CCC was achieved in all eyes in the 3 groups. Two eyes each in the fluorescein and autologous blood groups had extension of the CCC so that the capsulorhexis was complete but not curvilinear. Anterior capsule fibrosis was detected with trypan blue (1 eye) and ICG (2 eyes). The anterior vitreous was stained with fluorescein in 2 eyes. All eyes achieved a BCVA of 20/30 or better from 1 week postoperatively to the last follow-up. The side port and corneal tunnel were stained most intensely with gentian violet followed by trypan blue and ICG and less intensely with fluorescein and autologous blood. The IOP, pachymetry, and endothelial cell loss were comparable between the stains.
Although trypan blue, ICG, gentian violet, fluorescein, and autologous blood were safely used to stain the anterior capsule for phacoemulsification in eyes with white cataract, trypan blue, ICG, and gentian violet were more effective in staining the capsule.
比较0.1%台盼蓝、0.001%龙胆紫、0.5%吲哚菁绿（ICG）、2%荧光素以及患者自体血用于白色白内障病例前囊染色的安全性和有效性。
印度新德里全印医学科学研究所拉金德拉·普拉萨德眼科科学中心。
50例年龄相关性白色白内障患者的50只眼，分别采用台盼蓝、ICG或龙胆紫在气泡下或用荧光素或自体血在囊膜下进行前囊染色，随后行超声乳化折叠式人工晶状体植入术。每种染色剂用于10只眼。记录制作连续环形撕囊（CCC）的难易程度以及手术中的并发症。术后6小时、1天、1周和1个月的检查包括裂隙灯显微镜检查、未矫正视力和最佳矫正视力（BCVA）。术中、术后6小时内和1天时评估前囊、侧切口、角膜隧道和前皮质的染色模式。术后1天测量眼压（IOP）；术后1天和1个月测量角膜厚度；术后1个月测量内皮细胞计数。
使用台盼蓝、ICG和龙胆紫进行前囊撕囊时，术者视野最佳，3组所有眼均成功完成CCC。荧光素组和自体血组各有2只眼的CCC延长，使得撕囊完整但不是环形。台盼蓝组（1只眼）和ICG组（2只眼）检测到前囊纤维化。2只眼的前玻璃体被荧光素染色。从术后1周直至最后一次随访，所有眼的BCVA均达到20/30或更好。侧切口和角膜隧道被龙胆紫染色最深，其次是台盼蓝和ICG，荧光素和自体血染色较浅。各染色剂之间的IOP、角膜厚度测量值和内皮细胞损失相当。
虽然台盼蓝、ICG、龙胆紫、荧光素和自体血均可安全用于白色白内障眼的前囊染色以进行超声乳化，但台盼蓝、ICG和龙胆紫在囊膜染色方面更有效。
