Pollinger K, Hennig R, Bauer S, Breunig M, Tessmar J, Buschauer A, Witzgall R, Goepferich A
J Nanosci Nanotechnol. 2014 May;14(5):3313-9. doi: 10.1166/jnn.2014.8716.
The biodistribution of nanoparticles is a major subject of current nanomedical research. To date, however, the exact investigation of nanoparticle fate in the microenvironment of a main excretory organ, the kidney has largely been neglected. In this study, the biodistribution of polyethylene glycol-coated quantum dots (Qdots) with special focus on their interaction with the kidney is investigated. Upon intravenous injection, nanoparticles showed effective blood circulation in mice and significant renal accumulation after two hours. Histological analysis of the kidney revealed that Qdots were strongly associated to the intraglomerular mesangial cells. This preferential deposition of nanoparticles in the kidney mesangium is highly promising, since it could be of utmost value for site-specific treatment of severe kidney diseases like diabetic nephropathy in the future.
纳米颗粒的生物分布是当前纳米医学研究的一个主要课题。然而，迄今为止，在主要排泄器官肾脏的微环境中对纳米颗粒命运的确切研究在很大程度上被忽视了。在本研究中，研究了聚乙二醇包覆量子点（Qdots）的生物分布，特别关注它们与肾脏的相互作用。静脉注射后，纳米颗粒在小鼠体内显示出有效的血液循环，并在两小时后在肾脏中显著蓄积。肾脏的组织学分析表明，量子点与肾小球系膜细胞密切相关。纳米颗粒在肾脏系膜中的这种优先沉积非常有前景，因为它未来可能对糖尿病肾病等严重肾脏疾病的位点特异性治疗具有极高的价值。
