Choi Hak Soo, Ipe Binil Itty, Misra Preeti, Lee Jeong Heon, Bawendi Moungi G, Frangioni John V
Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.
Nano Lett. 2009 Jun;9(6):2354-9. doi: 10.1021/nl900872r.
A significant portion of the field of nanomedicine is predicated on being able to target nanoparticles to sites of disease. However, in vivo biodistribution and clearance of nanoparticles are poorly understood. In this study, a novel formulation of near-infrared fluorescent InAs(ZnS) quantum dots was synthesized and coated with a systematically increasing chain length of PEG. We found that varying PEG chain length resulted in major changes in organ/tissue-selective biodistribution and clearance from the body.
纳米医学领域的很大一部分是基于能够将纳米颗粒靶向疾病部位。然而，纳米颗粒在体内的生物分布和清除情况却知之甚少。在本研究中，合成了一种新型的近红外荧光InAs(ZnS)量子点制剂，并用链长逐步增加的聚乙二醇（PEG）进行包被。我们发现，改变PEG链长会导致器官/组织选择性生物分布和从体内清除的重大变化。
