Agotegaray Mariela, Palma Santiago, Lassalle Verónica
J Nanosci Nanotechnol. 2014 May;14(5):3343-7. doi: 10.1166/jnn.2014.8256.
New magnetic devices consisting of magnetite functionalized with oleic acid and chitosan have been synthesized and employed to the loading of Diclofenac as potential tool for treatment of targeted inflammatory diseases. Magnetic loaded and un-loaded nanoparticles have been thoroughly characterized by infrared spectroscopy, transmission electron microscopy, determination of hydrodynamic diameter by Dynamic light scattering and zeta potential measurements at different pH conditions. A study of the release of Diclofenac has been performed in vitro and available mathematical models have been used to determine the release kinetic. Both properties and release data reveal that this nanomagnetic platform would be suitable for in vivo assays.
已合成了由用油酸和壳聚糖功能化的磁铁矿组成的新型磁性装置，并将其用于双氯芬酸的负载，作为治疗靶向炎症性疾病的潜在工具。通过红外光谱、透射电子显微镜、动态光散射法测定流体动力学直径以及在不同pH条件下测量zeta电位，对负载和未负载磁性的纳米颗粒进行了全面表征。已在体外进行了双氯芬酸释放的研究，并使用现有的数学模型来确定释放动力学。性质和释放数据均表明，这种纳米磁性平台适用于体内试验。
