Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
Drug Dev Ind Pharm. 2013 Aug;39(8):1217-29. doi: 10.3109/03639045.2012.707205. Epub 2012 Aug 9.
A complex of low molecular weight chitosan (LMWC) with oleic acid and diclofenac potassium (DP) was prepared and dispersed in high concentrations of polysorbate 20, 60 and 80 in water to form a solution which releases its components slowly. The formed complex was characterized using different analytical methods. The size of the resulted nanoparticles and the effect of tweens on size were followed using dynamic light scattering (DLS). The release of DP from this delivery system was monitored by altering the molecular weight of chitosan and the type and concentration of the polysorbates used. The most suitable preparation consisted of DP, LMWC 13 kDa, and oleic acid. This was dispersed in 5% Tween 80 and the release was followed by the adaptation of USP II apparatus using a cellophane bag. This preparation offers a release of up to 24 h.
一种低分子量壳聚糖（LMWC）与油酸和双氯芬酸钾（DP）的复合物，被制备并分散在高浓度的聚山梨酯 20、60 和 80 中，在水中形成一种缓慢释放其成分的溶液。该复合物通过不同的分析方法进行了表征。使用动态光散射（DLS）跟踪了所得纳米颗粒的大小以及吐温对大小的影响。通过改变壳聚糖的分子量以及聚山梨酯的类型和浓度来监测 DP 从该递药系统中的释放。最合适的制备物由 DP、LMWC（分子量 13 kDa）和油酸组成。将其分散在 5%的吐温 80 中，并通过使用纤维素膜袋适应 USP II 装置来跟踪释放。该制剂可提供长达 24 小时的释放。
