前列腺素E2对兔而非人支气管神经传递的抑制作用——一种与钙相关的机制？

Inhibition by prostaglandin E2 of neurotransmission in rabbit but not human bronchus--a calcium-related mechanism?

作者信息

Black J L, Johnson P R, Alfredson M, Armour C L

机构信息

Department of Pharmacology, University of Sydney, Australia.

出版信息

Prostaglandins. 1989 Mar;37(3):317-30. doi: 10.1016/0090-6980(89)90002-6.

DOI:10.1016/0090-6980(89)90002-6

PMID:2473495

Abstract

Prostaglandins have been implicated in the development of airway hyperresponsiveness, and this may be mediated via modulation of neurotransmission. We compared the effects of prostaglandin E2 on the contractile response to electrical field stimulation in rabbit and human bronchus. Prostaglandin E2 produced marked inhibition in rabbit bronchus (mean % inhibition 35 +/- 17, P less than 0.05) but was without effect in human bronchus. The inhibition in rabbit bronchus was not the result of a direct effect on muscle tone and the site of action is likely to be pre-synaptic since prostaglandin E2 had only minor effects on exogenous acetylcholine. Since prostaglandins are known to affect calcium mobilization, we compared the dependence of cholinergic stimulation on the calcium voltage dependent channel (VDC) in the two species. Cholinergic stimulation was dependent on the VDC in rabbit but not human bronchus and this may be an explanation for the different effects of prostaglandin E2 in the two species.

摘要

前列腺素与气道高反应性的发生有关，这可能是通过调节神经传递介导的。我们比较了前列腺素E2对兔和人支气管电场刺激收缩反应的影响。前列腺素E2对兔支气管产生显著抑制作用（平均抑制率35±17，P<0.05），但对人支气管无作用。兔支气管中的抑制作用不是对肌张力直接作用的结果，作用部位可能是突触前，因为前列腺素E2对外源性乙酰胆碱只有轻微影响。由于已知前列腺素会影响钙动员，我们比较了两种动物中胆碱能刺激对钙电压依赖性通道（VDC）的依赖性。胆碱能刺激在兔支气管中依赖于VDC，而在人支气管中则不依赖，这可能解释了前列腺素E2在两种动物中的不同作用。