来自牛角瓜树皮的强心甾类化合物。
Cardenolides from the bark of Calotropis gigantea.
作者信息
Van Khang Pham, Zhang Zhong-Guo, Meng Yu-Hui, Guo De-An, Liu Xuan, Hu Li-Hong, Ma Lei
机构信息
a Shanghai Key Laboratory of New Drug Design , School of Pharmacy, East China University of Science and Technology , 130 Meilong Road, Shanghai 200237 , P.R. China.
出版信息
Nat Prod Res. 2014;28(15):1191-6. doi: 10.1080/14786419.2014.909419. Epub 2014 Apr 16.
Three new cardenolides (1-3) were isolated from the 90% ethanolic extract of the bark of a wild-type Calotropis gigantea. Their structures were determined by using NMR spectra and LC-MS analysis. Their inhibitory activities were evaluated against non-small cell lung carcinoma (A549) and human cervix epithelial adenocarcinoma (HeLa) cell lines. Compounds 1 and 3 exhibited strong inhibitory effect on two cancer cell lines.
从野生型牛角瓜树皮的90%乙醇提取物中分离出三种新的强心苷（1-3）。通过核磁共振光谱和液相色谱-质谱分析确定了它们的结构。评估了它们对非小细胞肺癌（A549）和人宫颈上皮腺癌（HeLa）细胞系的抑制活性。化合物1和3对两种癌细胞系表现出强烈的抑制作用。
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