从大猪屎青根皮中分离得到的细胞毒强心甾苷。

Cytotoxic cardenolides from the root bark of Calotropis gigantea.

机构信息

School of Pharmacy, East China University of Science and Technology, Shanghai 200237, People's Republic of China.

出版信息

Steroids. 2013 Oct;78(10):1029-34. doi: 10.1016/j.steroids.2013.06.002. Epub 2013 Jul 12.

DOI:10.1016/j.steroids.2013.06.002

Abstract

Six new cardenolides (1, 2 and 11-14), along with ten known ones, were isolated from the root bark of Calotropis gigantea. The structural determination was accomplished by the 1D- and 2D-NMR spectrum as well as ESIMS analysis. The isolated compounds were evaluated for their in vitro growth inhibitory activity against human A549 and Hela cell lines. The results suggested that some of these cardenolides (compounds 1, 6, and 8) displayed potent cytotoxicities.

摘要

从大猪笼草的根皮中分离得到了六个新的强心苷（1、2 和 11-14）以及十个已知的强心苷。通过 1D 和 2D-NMR 光谱以及 ESIMS 分析完成了结构测定。对分离得到的化合物进行了体外生长抑制活性评价，以评估其对人 A549 和 Hela 细胞系的抑制活性。结果表明，其中一些强心苷（化合物 1、6 和 8）表现出很强的细胞毒性。