Department of Otolaryngology-Head and Neck Surgery, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands.
Department of Otolaryngology-Head and Neck Surgery, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands.
Oral Oncol. 2014 Jul;50(7):670-5. doi: 10.1016/j.oraloncology.2014.03.008. Epub 2014 Apr 13.
Incidence and survival trends of head and neck squamous cell carcinoma (HNSCC) are essential knowledge for guiding policy making and research.
The total population of the Netherlands was studied covering 1989-2011. Two-and five-year survival and age-standardized incidence rates of HNSCC were assessed in relation to site, gender and age (15 years-of-age categories).
We recorded a statistically significant increase of oral, oropharyngeal and hypopharyngeal carcinoma for males and females of all ages, varying from 0.6% (hypopharynx in males) to 2.7% (oropharynx in females) per year. The incidence of laryngeal carcinoma significantly decreased for males with 2.3% per year; for females the situation was stable. In young adults (below 45 years of age) the incidence figures were different: significant decreasing incidence trends were seen for both genders for carcinomas of the oropharynx, hypopharynx and larynx. Regarding oral carcinoma, no change was observed for the young patient group, but for subsites trends were divergent. Carcinoma of the floor or mouth decreased for both genders, but carcinoma of the tongue rose by a significant 2.8% per year for young males. Five-year survival trends for all ages showed no change for laryngeal carcinoma, a small improvement for oral and hypopharyngeal carcinoma, and a substantial and significant improvement of survival from 36% to 47% survival over the total period for oropharyngeal carcinoma.
In the Netherlands for the last two decades, the incidence of oral, oropharyngeal and hypopharyngeal squamous cell carcinoma has increased and survival has improved. The incidence of laryngeal carcinoma has decreased in males, and remained unchanged in females; survival from laryngeal carcinoma has not changed.
头颈部鳞状细胞癌（HNSCC）的发病率和生存率趋势是指导政策制定和研究的重要知识。
研究了荷兰的总人口，涵盖了 1989 年至 2011 年的数据。评估了 HNSCC 的两年和五年生存率以及年龄标准化发病率，与部位、性别和年龄（15 岁年龄组）有关。
我们记录到男性和女性所有年龄段的口腔、口咽和下咽癌的发病率呈统计学显著增加，每年变化范围为 0.6%（男性下咽）至 2.7%（女性口咽）。男性喉癌的发病率每年显著下降 2.3%；女性情况稳定。在年轻成年人（45 岁以下）中，发病率不同：男性和女性的口咽、下咽和喉癌的发病率呈显著下降趋势。对于口腔癌，年轻患者组没有观察到变化，但亚部位的趋势不同。男性和女性的口腔底部或口腔癌都在减少，但男性舌癌的发病率每年显著增加 2.8%。所有年龄段的五年生存率趋势显示，喉癌没有变化，口腔和下咽癌略有改善，口咽癌的生存率从整个时期的 36%提高到 47%，有实质性和显著改善。
在过去二十年中，荷兰口腔、口咽和下咽鳞状细胞癌的发病率增加，生存率提高。男性喉癌的发病率下降，女性不变；喉癌的生存率没有变化。
