van der Aa Pepijn J P, Witjes Max J H, van der Vegt Bert, Schuuring Ed, Boeve Koos, Sidorenkov Grigory, de Bock Geertruida H, de Visscher Sebastiaan A H J
Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Oral Dis. 2025 Jul;31(7):2129-2138. doi: 10.1111/odi.15235. Epub 2024 Dec 30.
This study aimed to explore differences in demographics, tumour characteristics and outcomes in oral squamous cell carcinoma (OSCC) patients with a history of non-smoking, non-drinking (NSND) versus smoking and/or drinking (SD).
Newly diagnosed OSCC patients undergoing curative surgical treatment were prospectively included in OncoLifeS, a data biobank. Cox regression analysis was performed yielding hazard ratios (HRs) and 95% confidence intervals (95%CIs).
185 patients were included, and 32.4% of patients were NSND; this group represented an older (69 vs. 64.4 years, p < 0.01) and more female-dominated (66.7% vs. 44.5%, p = 0.02) population. NSND patients had more tongue tumours (68.3% vs. 46.4%, p < 0.01) and few floor-of-mouth tumours (1.7% vs. 20.0%, p < 0.01). Locoregional recurrence, overall survival and disease-specific survival risk were similar between the NSND and SD patients. NSND patients had a higher second primary tumour risk compared to SD patients in the multivariable analysis (adjusted HR 3.92, 1.23-12.48, p = 0.02).
NSND patients with OSCC have a distinct clinicopathological profile compared to SD patients, with a higher risk of second primary tumours after treatment. These differences in risk profiles should be considered in future OSCC management strategies.
本研究旨在探讨有不吸烟、不饮酒（NSND）史与有吸烟和/或饮酒（SD）史的口腔鳞状细胞癌（OSCC）患者在人口统计学、肿瘤特征及预后方面的差异。
前瞻性纳入OncoLifeS（一个数据生物样本库）中接受根治性手术治疗的新诊断OSCC患者。进行Cox回归分析，得出风险比（HRs）和95%置信区间（95%CIs）。
共纳入185例患者，32.4%的患者为NSND；该组患者年龄较大（69岁对64.4岁，p<0.01），且女性占比更高（66.7%对44.5%，p=0.02）。NSND患者舌部肿瘤更多（68.3%对46.4%，p<0.01），口底肿瘤较少（1.7%对20.0%，p<0.01）。NSND和SD患者的局部区域复发、总生存及疾病特异性生存风险相似。多变量分析显示，NSND患者发生第二原发性肿瘤的风险高于SD患者（校正HR 3.92，1.23 - 12.48，p=0.02）。
与SD患者相比，OSCC的NSND患者具有独特的临床病理特征，治疗后发生第二原发性肿瘤的风险更高。在未来的OSCC管理策略中应考虑这些风险特征的差异。
