Linnebjerg H, Hansen H S, Jensen B
Pharma Biotec Research Center, Royal Danish School of Pharmacy, Copenhagen, Denmark.
Agents Actions. 1989 Apr;27(1-2):39-42. doi: 10.1007/BF02222192.
The effect of a putative Na+/H+ exchange inhibition on histamine and [14C]arachidonic acid ([14C]AA) release has been examined in rat peritoneal mast cells, using either addition of amiloride or removal of extracellular Na+. The cells were stimulated by non-immunological agents, i.e. calcium ionophore A23187, nerve growth factor (NGF), thapsigargin and compound 48/80. On the basis of the results obtained, a possible role for Na+/H+ exchange in rat mast cell secretion is discussed.
在大鼠腹膜肥大细胞中，通过添加氨氯吡咪或去除细胞外钠离子，研究了假定的钠/氢交换抑制对组胺和[14C]花生四烯酸（[14C]AA）释放的影响。细胞由非免疫性试剂刺激，即钙离子载体A23187、神经生长因子（NGF）、毒胡萝卜素和化合物48/80。根据所得结果，讨论了钠/氢交换在大鼠肥大细胞分泌中的可能作用。
