Fernández Muñoz María J, Basurto Acevedo Lourdes, Córdova Pérez Nydia, Vázquez Martínez Ana Laura, Tepach Gutiérrez Nayive, Vega García Sara, Rocha Cruz Alberto, Díaz Martínez Alma, Saucedo García Renata, Zárate Treviño Arturo, González Escudero Eduardo Alberto, Degollado Córdova José Antonio
Servicio de Cardiología, Hospital de Especialidades, Centro Médico Nacional del Instituto Mexicano del Seguro Social, México DF, Mexico.
Unidad de Investigación Médica en Enfermedades Endocrinas, Centro Médico Nacional del Instituto Mexicano del Seguro Social, México DF, Mexico.
Rev Esp Cardiol (Engl Ed). 2014 Jun;67(6):436-41. doi: 10.1016/j.rec.2013.10.011. Epub 2014 Feb 12.
Epicardial adipose tissue has been associated with several obesity-related parameters and with insulin resistance. Echocardiographic assessment of this tissue is an easy and reliable marker of cardiometabolic risk. However, there are insufficient studies on the relationship between epicardial fat and insulin resistance during the postmenopausal period, when cardiovascular risk increases in women. The objective of this study was to examine the association between epicardial adipose tissue and visceral adipose tissue, waist circumference, body mass index, and insulin resistance in postmenopausal women.
A cross sectional study was conducted in 34 postmenopausal women with and without metabolic syndrome. All participants underwent a transthoracic echocardiogram and body composition analysis.
A positive correlation was observed between epicardial fat and visceral adipose tissue, body mass index, and waist circumference. The values of these correlations of epicardial fat thickness overlying the aorta-right ventricle were r = 0.505 (P < .003), r = 0.545 (P < .001), and r = 0.515 (P < .003), respectively. Epicardial adipose tissue was higher in postmenopausal women with metabolic syndrome than in those without this syndrome (mean [standard deviation], 544.2 [122.9] vs 363.6 [162.3] mm(2); P = .03).
Epicardial fat thickness measured by echocardiography was associated with visceral adipose tissue and other obesity parameters. Epicardial adipose tissue was higher in postmenopausal women with metabolic syndrome. Therefore, echocardiographic assessment of epicardial fat may be a simple and reliable marker of cardiovascular risk in postmenopausal women.
心外膜脂肪组织与多种肥胖相关参数及胰岛素抵抗有关。对该组织进行超声心动图评估是心脏代谢风险的一种简便且可靠的标志物。然而，在绝经后女性心血管风险增加的这一时期，关于心外膜脂肪与胰岛素抵抗之间关系的研究尚不充分。本研究的目的是探讨绝经后女性心外膜脂肪组织与内脏脂肪组织、腰围、体重指数及胰岛素抵抗之间的关联。
对34名有或无代谢综合征的绝经后女性进行了一项横断面研究。所有参与者均接受了经胸超声心动图检查和身体成分分析。
观察到心外膜脂肪与内脏脂肪组织、体重指数和腰围之间呈正相关。覆盖在主动脉 - 右心室上方的心外膜脂肪厚度与这些指标的相关性值分别为r = 0.505（P <.003），r = 0.545（P <.001）和r = 0.515（P <.003）。有代谢综合征的绝经后女性的心外膜脂肪组织高于无该综合征的女性（均值[标准差]，544.2 [122.9] vs 363.6 [162.3] mm²；P =.03）。
通过超声心动图测量的心外膜脂肪厚度与内脏脂肪组织及其他肥胖参数相关。有代谢综合征的绝经后女性的心外膜脂肪组织更高。因此，超声心动图评估心外膜脂肪可能是绝经后女性心血管风险的一种简单且可靠的标志物。
