Jin Bo, Dong Yu, Zhang Xueyan, Wang Huimin, Han Baohui
Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China.
PLoS One. 2014 Apr 15;9(4):e93937. doi: 10.1371/journal.pone.0093937. eCollection 2014.
Xeroderma pigmentosum complementation group C gene (XPC) is a key member of nucleotide excision repair pathway and plays an important role in human DNA repair system. It is reported that several common polymorphisms of XPC are associated with susceptibility to lung cancer. However, the conclusion is still elusive.
This meta-analysis was performed to determine the relationship between XPC polymorphisms (Lys939Gln, Ala499Val, and PAT) and lung cancer risk. Published literatures were identified by searching online databases and reference lists of relevant studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the association strength. Publication bias were detected by Egger's and Begg's test.
After strict screening, we identified 14 eligible studies in this meta-analysis, including 5647 lung cancer cases and 6908 controls. By pooling all eligible studies, we found that the homozygote Gln939Gln genotype was associated with a significantly increased risk of lung cancer in Asian population (GlnGln vs LysLys, OR=1.229, 95% CI: 1.000-1.510; GlnGln vs LysLys/LysGln, OR=1.257, 95% CI: 1.038-1.522). As for the PAT polymorphism, in Caucasian population, we found carriers of the -/- genotype were associated significantly reduced risk of lung cancer in homozygote comparison model (-/- vs +/+, OR=0.735, 95% CI: 0.567-0.952).
In this meta-analysis we found that Gln939Gln genotype was associated with significantly increased risk of lung cancer in Asian population; the PAT -/- genotype significantly reduced susceptibility to lung cancer in Caucasian population; while the XPC Ala499Val polymorphism was not associated with lung cancer risk.
着色性干皮病C互补组基因（XPC）是核苷酸切除修复途径的关键成员，在人类DNA修复系统中起重要作用。据报道，XPC的几种常见多态性与肺癌易感性相关。然而，结论仍不明确。
进行这项荟萃分析以确定XPC多态性（Lys939Gln、Ala499Val和PAT）与肺癌风险之间的关系。通过搜索在线数据库和相关研究的参考文献列表来识别已发表的文献。计算比值比（OR）和95%置信区间（CI）以估计关联强度。通过Egger检验和Begg检验检测发表偏倚。
经过严格筛选，我们在这项荟萃分析中确定了14项符合条件的研究，包括5647例肺癌病例和6908例对照。通过汇总所有符合条件的研究，我们发现纯合子Gln939Gln基因型与亚洲人群肺癌风险显著增加相关（GlnGln与LysLys相比，OR = 1.229，95% CI：1.000 - 1.510；GlnGln与LysLys/LysGln相比，OR = 1.257，95% CI：1.038 - 1.522）。至于PAT多态性，在白种人群中，我们发现在纯合子比较模型中，-/-基因型携带者的肺癌风险显著降低（-/-与+/+相比，OR = 0.735，95% CI：0.567 - 0.952）。
在这项荟萃分析中，我们发现Gln939Gln基因型与亚洲人群肺癌风险显著增加相关；PAT -/-基因型显著降低白种人群对肺癌的易感性；而XPC Ala499Val多态性与肺癌风险无关。
