Dai Qiang-Sheng, Hua Rui-Xi, Zeng Rui-Fang, Long Jian-Ting, Peng Zhen-Wei
Department of Oncology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, 510080, People's Republic of China,
Tumour Biol. 2014 Jan;35(1):447-53. doi: 10.1007/s13277-013-1062-y. Epub 2013 Aug 6.
Numerous studies have investigated the association between three polymorphisms (Lys939Gln, Ala499Val and PAT-/+) of Xeroderma pigmentosum group C (XPC) gene and bladder cancer susceptibility; however, the findings are inconclusive. In order to acquire a more precise estimation of the relationship, we performed a meta-analysis based on 10 studies including 3,934 cases and 4,269 controls for Lys939Gln, five studies including 2,113 cases and 2,249 controls for Ala499Val, and seven studies including 2,834 cases and 3,048 controls for PAT-/+ polymorphism. We searched publications from EMBASE, MEDLINE, and Chinese Biomedical. We calculated pooled odds ratio (OR) and 95% confidence interval (CI) by using either fixed-effects or random-effects model according to the between-study heterogeneity. We found that all studied polymorphisms were individually associated with increased overall cancer risks, as shown by ORs (95% CIs) below: the Lys939Gln (Gln/Gln vs. Lys/Lys: OR = 1.39, 95% CI = 1.08-1.79; recessive model: OR = 1.42, 95% CI = 1.11-1.83; and allele comparing: OR = 1.12, 95% CI = 1.003-1.24), the Ala499Val (Val/Val vs. Ala/Ala: OR = 1.82, 95% CI = 1.19-2.79; recessive model: OR = 1.70, 95% CI = 1.18-2.46; and allele comparing: OR = 1.23, 95% CI = 1.01-1.50), and the PAT-/+ (+/+ vs. -/-: OR = 1.36, 95% CI = 1.03-1.79 and recessive model: OR = 1.34, 95% CI = 1.06-1.70). Furthermore, stratification analyses demonstrated an increased risk for Asian populations as to the Lys939Gln and PAT-/+ whereas for Caucasian populations as to the Ala499Val polymorphism in the homozygous and recessive models. Despite some limitations, this meta-analysis suggests that XPC polymorphisms are associated with bladder cancer risk, but this association warrants further validation in well-designed studies with large sample sizes.
众多研究调查了C组着色性干皮病（XPC）基因的三种多态性（Lys939Gln、Ala499Val和PAT - / +）与膀胱癌易感性之间的关联；然而，研究结果尚无定论。为了更精确地评估二者关系，我们基于10项研究进行了一项荟萃分析，其中Lys939Gln相关研究纳入3934例病例和4269例对照，Ala499Val相关研究纳入2113例病例和2249例对照，PAT - / +多态性相关研究纳入2834例病例和3048例对照。我们检索了EMBASE、MEDLINE和中国生物医学文献数据库中的出版物。根据研究间的异质性，我们使用固定效应模型或随机效应模型计算合并比值比（OR）和95%置信区间（CI）。我们发现，所有研究的多态性均与总体癌症风险增加单独相关，如下所示的OR（95% CI）：Lys939Gln（Gln/Gln与Lys/Lys相比：OR = 1.39，95% CI = 1.08 - 1.79；隐性模型：OR = 1.42，95% CI = 1.11 - 1.83；等位基因比较：OR = 1.12，95% CI = 1.003 - 1.24），Ala499Val（Val/Val与Ala/Ala相比：OR = 1.82，95% CI = 1.19 - 2.79；隐性模型：OR = 1.70，95% CI = 1.18 - 2.46；等位基因比较：OR = 1.23，95% CI = 1.01 - 1.50），以及PAT - / +（+ / +与 - / -相比：OR = 1.36，95% CI = 1.03 - 1.79；隐性模型：OR = 1.34，95% CI = 1.06 - 1.70）。此外，分层分析表明，在纯合子和隐性模型中，亚洲人群中Lys939Gln和PAT - / +多态性的风险增加，而白种人群中Ala499Val多态性的风险增加。尽管存在一些局限性，但这项荟萃分析表明XPC多态性与膀胱癌风险相关，但这种关联需要在设计良好的大样本研究中进一步验证。
