N-末端脑利钠肽前体与高血压患者代谢综合征呈负相关。
N-terminal pro-B-type natriuretic peptide is inversely associated with metabolic syndrome in hypertensive patients.
机构信息
Divisions of Cardiology (H-RC, J-CH, MYC, J-HW) and Nephrology (B-GH), Department of Internal Medicine, Buddhist Tzu Chi General Hospital, Hualien, Taiwan; Institute of Medical Sciences (H-RC, MYC), Tzu Chi University, Hualien, Taiwan; School of Medicine (B-GH, J-HW), Tzu Chi University, Hualien, Taiwan; and Institute of Epidemiology & Preventive Medicine (L-YW), College of Public Health, National Taiwan University, Taipei, Taiwan.
出版信息
Am J Med Sci. 2014 Sep;348(3):210-4. doi: 10.1097/MAJ.0000000000000234.
BACKGROUND
It has been shown that metabolic syndrome is associated with lower levels of plasma N-terminal pro-B-type natriuretic peptide (Nt-proBNP) in the general population. However, there is no study about the association between Nt-proBNP and metabolic syndrome in hypertensive patients.
AIM
: To elucidate the relationship between Nt-proBNP and components of metabolic syndrome in hypertensive patients.
METHODS
Fasting blood samples were obtained from 74 hypertensive patients in our institution. Plasma levels of Nt-proBNP and other biochemical data were measured. Metabolic syndrome and its components were defined using diagnostic criteria from the International Diabetes Federation.
RESULTS
Forty-four hypertensive patients met the criteria for metabolic syndrome. We found that plasma Nt-proBNP levels were lower in hypertensive patients with metabolic syndrome attributable to inverse relationships between Nt-proBNP and albumin, triglyceride, insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and pancreatic β-cell function (HOMA-β). We further performed a multivariable linear regression analysis. The result showed that HOMA-IR is the independent predictor of plasma Nt-proBNP levels in hypertensive patients.
CONCLUSIONS
Plasma Nt-proBNP levels are inversely associated with metabolic syndrome in hypertensive patients. HOMA-IR is the independent predictor of Nt-proBNP in hypertensive patients.
背景
在一般人群中，代谢综合征与较低水平的血浆 N 末端脑利钠肽前体（Nt-proBNP）有关。然而，在高血压患者中，关于 Nt-proBNP 与代谢综合征之间的关系还没有研究。
目的
阐明高血压患者 Nt-proBNP 与代谢综合征各组分之间的关系。
方法
从我院 74 例高血压患者中抽取空腹血样。测定血浆 Nt-proBNP 及其他生化数据。采用国际糖尿病联合会的诊断标准定义代谢综合征及其各组分。
结果
44 例高血压患者符合代谢综合征标准。我们发现，代谢综合征高血压患者的血浆 Nt-proBNP 水平较低，这与 Nt-proBNP 与白蛋白、甘油三酯、胰岛素、胰岛素抵抗评估的稳态模型（HOMA-IR）和胰岛β细胞功能（HOMA-β）呈负相关有关。我们进一步进行了多元线性回归分析。结果表明，HOMA-IR 是高血压患者血浆 Nt-proBNP 水平的独立预测因子。
结论
高血压患者的血浆 Nt-proBNP 水平与代谢综合征呈负相关。HOMA-IR 是高血压患者 Nt-proBNP 的独立预测因子。
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